膀胱小细胞癌30例并文献复习  

Small cell carcinoma of bladder:a report of 30 cases and literature review

作　　者：张龙[1] 文春森 刘宇[1] 刘菁菁 周玉贺 王丛巍 张正果 贾占奎[1] 杨锦建[1] ZHANG Long;WEN Chunsen;LIU Yu;LIU Jingjing;ZHOU Yuhe;WANG Congwei;ZHANG Zhengguo;JIA Zhankui;YANG Jinjian(Department of Urology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Pathology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院泌尿外科,河南郑州450052 [2]郑州大学第一附属医院病理科,河南郑州450052

出　　处：《现代泌尿外科杂志》2022年第6期503-506,共4页Journal of Modern Urology

摘　　要：目的探讨膀胱小细胞癌临床特征,提高对该疾病的认识与诊治。方法回顾性分析2011年8月-2020年6月郑州大学第一附属医院收治的30例病理确诊为膀胱小细胞癌患者的临床资料。男21例,女9例;年龄38~87岁,中位年龄72.5岁;25例患者因血尿就诊;中位肿瘤最大直径为41(8~96)mm;15例患者行膀胱根治术,13例行经尿道膀胱肿瘤电切术,2例未手术;10例患者接受术后辅助化疗;1例患者行放疗。结果2例膀胱镜取活检及28例术后病理回示中13例患者为单纯型膀胱小细胞癌,17例患者为混合型膀胱小细胞癌。30例患者随访时间3~62个月,其中21例死亡(19例死于远处转移、2例死于术后感染),中位存活时间为12(3~40)月,余9例随访10~62月无瘤生存至今。10例患者接受以铂类为主的术后辅助化疗,其中7例患者无瘤生存至今。结论膀胱小细胞癌侵袭性强、易转移、预后差,化疗联合膀胱根治术可作为首选治疗方案。Objective To explore the clinical characteristics of small cell carcinoma of bladder(SCCB)and to improve the understanding,diagnosis and treatment of this disease.Methods The clinical data of 30 SCCB patients treated in our hospital during Aug.2011 and Jun.2020 were retrospectively analyzed.The patients included 21 males and 9 females,age ranging from 38 to 87 years,with a median of 72.5 years.Among all patients,25 were admitted due to hematuria,and the median maximum tumor diameter was 41 mm(8-96 mm).Radical surgery was performed in 15 patients,transurethral resection of bladder tumor in 13 patients,and 2 patients did not receive surgical treatment.Postoperative chemotherapy was conducted in 10 patients,and radiotherapy in 1 patient.Results Cystoscopic biopsy was performed in 2 patients,and surgical pathological results were obtained in 28 patients,the results indicating simple SCCB in 13 patients and mixed SCCB in 17 patients.During the follow-up of 3~62 months,21 patients died,19 of whom died of distant metastasis and 2 died of postoperative infection.The median survival time of them was 12 months(3~40 months).The remaining 9 cases survived without tumor for 10~62 months up to now.Platinum-based adjuvant chemotherapy was performed in 10 patients,7 of whom survived disease-free to date.Conclusion SCCB is highly aggressive and easily metastatic with poor prognosis.Chemotherapy combined with radical cystectomy may be the preferred treatment.

关 键 词：膀胱肿瘤 膀胱小细胞癌 膀胱神经内分泌癌 临床特征 膀胱根治术 膀胱肿瘤电切术 化疗 

分 类 号：R737[医药卫生—肿瘤]