腹腔镜切除术与肝动脉化疗栓塞术治疗复发性肝癌效果比较  

Effect Comparison of Laparoscopic Resection and Hepatic Artery Chemoembolization in Treatment of Recurrent Liver Cancer

作　　者：韩冰[1] 李昌[1] 王仰亮 Han Bing;Li Chang;Wang Yang-liang(Department of Hepatobiliary Surgery,Shanxian Central Hospital,Heze 274300,Shandong Province,China)

机构地区：[1]单县中心医院肝胆外科,山东菏泽274300

出　　处：《中国社区医师》2022年第15期63-65,共3页Chinese Community Doctors

摘　　要：目的:对比腹腔镜切除术与肝动脉化疗栓塞术治疗复发性肝癌的效果。方法:选取2018年1月-2021年1月单县中心医院收治的64例复发性肝癌患者,随机数字表法分为两组,各32例。对照组行腹腔镜切除术;观察组行肝动脉化疗栓塞术。比较两组手术相关指标、细胞免疫功能指标、炎性反应指标及生存质量评分。结果:观察组患者手术时间、术后镇痛药物使用时间、首次进食时间和住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组成熟T淋巴细胞、诱导性T细胞、诱导性T细胞/抑制性T细胞及自然杀伤细胞水平均高于对照组,抑制性T细胞水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组C反应蛋白、趋化性细胞因子、白细胞介素-1β及肿瘤坏死因子-α水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组生存质量评分高于对照组,差异有统计学意义(P<0.05)。结论:肝动脉化疗栓塞术比腹腔镜切除术更能提高手术效果,保障治疗安全性,对于难以手术的复发性肝癌,肝动脉化疗栓塞术的临床应用价值更高。Objective:To compare the effects of laparoscopic resection and hepatic artery chemoembolization in the treatment ofrecurrent liver cancer.Methods:A total of 64 patients with recurrent liver cancer admitted to Shanxian Central Hospital fromJanuary 2018 to January 2021 were selected.According to random number table method,they were divided into two groups,with32 cases in each group.The control group underwent laparoscopic resection,and the observation group underwent hepatic arterychemoembolization.The operation-related indicators,cellular immune function indicators,inflammatory response indicators andquality of life scores were compared between the two groups.Results:The operation time,postoperative analgesic use time,firstmeal time and hospitalization time of the observation group were shorter than those in the control group,with statisticallysignificant difference(P<0.05).After treatment,the levels of mature T lymphocytes,induced T cells,induced T cells/inhibitory Tcells and natural killer cells in the observation group were higher than those in the control group,and the levels of inhibitory Tcells were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levelsof C-reactive protein,chemotactic cytokines,interleukin-1β and tumor necrosis factor-α in the observation group were lower thanthose in the control group,and the difference was statistically significant(P<0.05).After treatment,the quality of life score in theobservation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Compared with laparoscopic resection,hepatic artery chemoembolization can further improve the surgical effect and ensure thesafety of treatment.For recurrent liver cancer that is difficult to operate,hepatic artery chemoembolization has higher clinicalapplication value.

关 键 词：肝动脉化疗栓塞术 腹腔镜切除术 复发性肝癌 

分 类 号：R735.7[医药卫生—肿瘤]