年龄相关性黄斑变性炎症相关机制的研究进展  

Research progress on inflammation related mechanisms of age-related macular degeneration

作　　者：马培茹 刘羊钰 李水 杨华静[1] 陈建斌[1] MA Peiru;LIU Yangyu;LI Shui;YANG Huajing;CHEN Jianbin(Ophthalmology Department of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430000,China)

机构地区：[1]华中科技大学同济医学院附属同济医院眼科,武汉430000

出　　处：《生命的化学》2022年第4期752-758,共7页Chemistry of Life

基　　金：湖北省自然科学基金项目(2012FKB02444)。

摘　　要：年龄相关性黄斑变性(age-related macular degeneration,AMD)是一种随着年龄增长发病率逐渐升高的视网膜退行性疾病,可造成不可逆性视力下降,也是一种多因素疾病,其发病机制目前尚未完全明确。炎症反应作为AMD最重要的发病机制之一,参与了AMD的发生和进展过程。其中,NLRP3炎症小体活化、补体级联途径介导、模式识别受体激活以及细胞因子与炎症细胞网络调控等机制与AMD的发病密切相关。针对炎症机制的研究可加深对AMD的认知,指导疾病的筛查和治疗,现将AMD中上述机制的研究进展作一综述。Age-related macular degeneration(AMD) is a retinal degenerative disease whose incidence gradually increases with age,which can cause irreversible vision loss.It is also a multifactorial disease,and its pathogenesis is not yet fully clear.As one of the most important pathogenesis,inflammation is involved in the occurrence and progression of AMD.In the mechanisms of inflammation,NLRP3 inflammasome activation,complement cascade pathway mediation,pattern recognition receptor activation,cytokine and inflammatory cell network regulation are closely related to the pathogenesis of AMD.The study of inflammatory mechanisms can deepen the understanding,guide the screening and treatment of AMD.In this paper,the latest researches on the above mechanisms in AMD will be reviewed.

关 键 词：年龄相关性黄斑变性 炎症 细胞因子 补体 

分 类 号：R774.5[医药卫生—眼科]