特发性快速眼动期睡眠行为障碍患者的多项睡眠图  

Polysomnography in patients with idiopathic rapid eye movement sleep behavior disorder

作　　者：罗玲[1] 陈荣华[1] 肖迎春[1] 余尔涵 潘晓东[1] LUO Ling;CHEN Ronghua;XIAO Yingchun(Department of Neurology,Fujian Medical University Union Hospital,Fuzhou(350001),Fujian,China)

机构地区：[1]福建医科大学附属协和医院神经内科,福建福州350001

出　　处：《癫痫与神经电生理学杂志》2022年第3期163-167,共5页Journal of Epileptology and Electroneurophysiology(China)

基　　金：福建医科大学启航基金(2020QH1069)。

摘　　要：目的探讨特发性快动眼睡眠行为障碍(iRBD)患者在多项睡眠监测下(PSG)睡眠结构和快速眼动期肌肉失弛缓(RSWA)严重程度及特点。方法选取2018年8月至2021年8月就诊于福建医科大学附属协和医院神经内科的iRBD患者共156例(iRBD组)以及同期来体检的健康人群101例(对照组),所有人行PSG监测。分析iRBD组和对照组受检者睡眠结构特点和RSWA参数结果,并对两者进行相关性分析。结果iRBD组睡眠结构紊乱,片段化,慢波睡眠减少,周期性肢体运动(PLM)相关指数增高。iRBD患者RSWA现象明显,但男女亚组分析发现两组的下颌时相性肌张力增高指数、下颌紧张性肌张力增高指数无明显差异。下颌时相性肌张力增高指数与睡眠效率呈负相关。结论iRBD患者睡眠结构明显异常,男女患者RSWA严重程度相当,睡眠效率是iRBD患者RSWA严重程度的影响因素,提高iRBD患者的睡眠效率有助于降低iRBD患者的RSWA严重程度。Objective To investigate the sleep structure features and the severity and characteristics of rapid eye movement sleep without atonia(RSWA)in patients with idiopathic rapid eye movement sleep behavior disorder(iRBD)monitored by polysomnography(PSG).Methods From August 2018 to August 2021,a total of 156 iRBD patients in Department of Neurology,Fujian Medical University Union Hospital were selected as iRBD group,and 101 healthy persons undergoing physical examination during the same period were collected as control group.Two groups were given PSG monitoring.The characteristics of sleep structure and RSWA parameters in iRBD and control groups were analyzed.The correlation between sleep structure and RSWA parameters was analyzed.Results The iRBD group had disordered sleep structures,fragmentation,decreased slow-wave sleep and increased periodic limb movements(PLMs)-related indexes.iRBD patients had obvious RSWA,but there were no significant differences in the indexes of mandibular phase muscular hypertonia and the indexes of mandibular tonic muscular hypertonia between male and female subgroups.Mandibular phase hypertonia index was negatively correlated with sleep efficiency.Conclusion The sleep structures of iRBD patients are obviously abnormal,and the severity of RSWA in male and female patients is equal.Sleep efficiency is an influencing factor of the severity of RSWA in iRBD patients.Improving sleep efficiency of iRBD patients could help reduce RSWA severity.

关 键 词：特发性快速眼动期睡眠行为障碍 多项睡眠监测 睡眠结构 骨骼肌迟缓现象消失 

分 类 号：R749[医药卫生—神经病学与精神病学]