外周血NLR Gal-9表达与子宫内膜异位症患者盆腔疼痛及粘连的相关性分析  

Correlation Analysis of NLR Gal-9 Expression in Peripheral Blood with Pelvic Pain and Adhesions in Patients with Endometriosis

作　　者：朱慧[1] 赵纯[1] 曹曦霞 华桦[1] 刘娟[1] 徐琳[1] ZHU Hui;ZHAO Chun;CAO Xixia(Nanjing Maternal and Child Health Hospital, Jiangsu Nanjing 210000, China)

机构地区：[1]江苏省南京市妇幼保健院生殖健康科,江苏南京210000

出　　处：《河北医学》2022年第6期914-918,共5页Hebei Medicine

基　　金：国家自然科学基金资助项目,(编号:81971386)。

摘　　要：目的:探讨分析外周血NLR、Gal-9表达与子宫内膜异位症患者盆腔疼痛及粘连的相关性。方法:选取2019年7月至2020年7月我院进行手术治疗的124例子宫内膜异位症患者作为观察组;并选取同期住院的60例非子宫内膜异位症患者作为对照组。术中按照美国剩余协会修正标准分期法(RAFS)确定患者临床分期期别,并根据疼痛程度分级法(VRS)对患者盆腔疼痛程度进行分级,按照Hobson评分法对盆腔粘黏程度进行分级。根据血常规检查结果计算外周血中性粒细胞与淋巴细胞比值(NLR),并采用双抗体夹心酶联免疫分析法检测半乳糖凝集素-9(Gal-9)水平,分析其表达水平与患者盆腔疼痛及粘连的相关性。结果:观察组患者外周血NLR(2.67±0.64)、Gal-9(687.34±126.51)ng/L水平显著高于对照组的(2.13±0.38)、(329.56±94.23)ng/L,差异达到统计学意义(P<0.05);盆腔重度疼痛组患者外周血NLR、Gal-9表达水平显著高于盆腔中度疼痛组和轻度疼痛组,且组间比较差异具有统计学意义(P<0.05);盆腔重度粘黏组患者外周血NLR、Gal-9表达水平显著高于盆腔轻度粘黏组以及无粘连组,且组间比较差异达到统计学意义(P<0.05);将外周血NLR、Gal-9表达纳入Logistic回归方程,结果显示,外周血NLR、Gal-9表达与子宫内膜异位症病情程度呈正相关关系(P<0.05)。结论:外周血NLR、Gal-9表达与子宫内膜异位症患者盆腔疼痛及粘连程度呈正相关关系,可通过检测其水平为子宫内膜异位症患者早期诊断及病情程度评估提供指导依据。Objective:To explore and analyze the correlation between the expression of NLR and Gal-9 in peripheral blood and pelvic pain and adhesions in patients with endometriosis.Methods:A total of 124 patients with endometriosis who underwent surgical treatment in our hospital from July 2019 to July 2020 were selected as the observation group and 60 patients with non-endometriosis who were hospitalized during the same period were selected as the control group.During the operation,the clinical stage of the patients was determined according to the American Residual Association's revised standard staging method(RAFS),and the pelvic pain degree of the patients was graded according to the pain degree classification method(VRS),and the pelvic viscosity degree was graded according to the Hobson score method.The peripheral blood neutrophil-to-lymphocyte ratio(NLR)was calculated based on the results of routine blood tests,and the level of galactose lectin-9(Gal-9)was measured using a double antibody sandwich enzyme immunoassay to analyse the correlation between its expression level and the patients'pelvic pain and adhesions.Results:The peripheral blood NLR(2.67±0.64)and Gal-9(687.34±126.51)ng/L levels of the observation group were significantly higher than those of the control group(2.13±0.38)and(329.56±94.23)ng/L,and the difference reached statistical significance(P<0.05);the expression levels of NLR and Gal-9 in peripheral blood of patients in the severe pelvic pain group were significantly higher than those in the pelvic moderate pain group and mild pain group,and the difference between the groups was statistically significant(P<0.05);the expression levels of NLR and Gal-9 in peripheral blood were significantly higher in the group with severe pelvic adhesions than in the group with mild pelvic adhesions,and the difference between the groups reached statistical significance(P<0.05);the expression of NLR and Gal-9 in peripheral blood was included in the logistic regression equation,and the results showed that the expression

关 键 词：中性粒细胞与淋巴细胞比值 半乳糖凝集素-9 子宫内膜异位症 盆腔疼痛 盆腔粘连 

分 类 号：R73[医药卫生—肿瘤]