变异链球菌与白色念珠菌相互作用在龋病发生中的研究进展  

Research progress on the relationship between Streptococcus mutans and Candida albicans in caries

作　　者：李姗姗[1] 杨芳[2] Li Shanshan;Yang Fang(School of Stomatology,Qingdao University,Qingdao 266003,China;Stomatology Center,Qingdao Municipal Hospital,Qingdao 266071,China)

机构地区：[1]青岛大学口腔医学院,青岛266003 [2]青岛市市立医院口腔医学中心,青岛266071

出　　处：《国际口腔医学杂志》2022年第4期392-396,共5页International Journal of Stomatology

基　　金：国家自然科学基金(81670979)。

摘　　要：口腔微生物之间的相互作用对口腔疾病的发生至关重要。变异链球菌和白色念珠菌是幼儿龋病常见的致龋微生物。两种微生物之间可通过葡糖基转移酶、蔗糖、SigX因子、群体感应信号分子法尼醇、化合物代谢等多种方式相互协同或者拮抗致龋。本文主要综述了二者的致龋机制、在生物膜中的协同和抑制作用以及混合生物膜抗菌疗法如抗菌剂、化合物、光动力疗法等。从生物膜角度阐释两种微生物与龋病发生的关系以及抑制生物膜活性的方法,为开发龋病治疗新策略提供了新视角。The interaction among oral microbes is crucial for the occurrence of oral diseases.Streptococcus mutans and Candida albicans are common pathogenic microorganisms of childhood caries.The two kinds of microorganisms can cooperate or antagonize each other to cause caries through extracellular enzymes,quorum sensing signaling molecules,and compound metabolism.In this paper,the caries-inducing mechanism and synergistic and inhibitory effects in biofilm and the newly developed mixed biofilm as antibacterial therapy were reviewed.From the perspective of biofilm,the relationship between the two microorganisms and the occurrence of caries and the methods to inhibit the biofilm activity were explained.This work provides a new perspective for the development of new treatment strategies for dental caries.

关 键 词：龋病 变异链球菌 白色念珠菌 共生 抑制 生物膜 

分 类 号：R780.2[医药卫生—口腔医学]