光热治疗在口腔鳞状细胞癌治疗中的研究进展  

Research progress on the use of photothermal therapy to treat oral squamous cell carcinoma

作　　者：赵卓平 辛鹏飞 高阳 张彩凤 张宽收[5] 刘青梅 Zhao Zhuoping;Xin Pengfei;Gao Yang;Zhang Caifeng;Zhang Kuanshou;Liu Qingmei(Shanxi Medical University,School and Hospital of Stomatology,Taiyuan 030001,China;Dept of Stomatology,Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,China;Tongji Hosptial,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Dept.of Chemistry,Taiyuan Normal University,Shanxi Humic Acid Engineering Technology Research Center,Jinzhong 030619,China;State Key Laboratory of Quantum Optics and Quantum Optics Devices,Institute of Opto-Electronics,Shanxi University,Collaborative Innovation Center of Extreme Optics,Shanxi University,Taiyuan 030006,China)

机构地区：[1]山西医科大学口腔医学院·口腔医院,太原030001 [2]山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院)口腔科,太原030032 [3]华中科技大学同济医学院附属同济医院,武汉430030 [4]太原师范学院化学系山西省腐植酸工程技术研究中心,晋中030619 [5]山西大学量子光学与光量子器件国家重点实验室山西大学光电研究所极端光学协同创新中心,太原030006

出　　处：《国际口腔医学杂志》2022年第4期462-470,共9页International Journal of Stomatology

基　　金：山西省卫生健康委员会科研课题(2018017);山西省“1331工程”协同创新中心建设计划项目;量子光学与光量子器件国家重点实验室(山西大学)开放课题(KF202105)。

摘　　要：目前,对于口腔鳞状细胞癌(OSCC)临床应用和研究较多的治疗手段主要包括手术、放射治疗、化学治疗、传统热疗、基因疗法、免疫疗法和光动力疗法(PDT)等,但治疗效果有限并伴有不同程度的不良反应。光热治疗(PTT)是一种新型的治疗方法,通过光热效应选择性杀伤癌细胞,具有较高的安全性。近红外光(NIR)具有良好的组织穿透性,光热转换剂(PTCA)具有可修饰性和选择性,它们是光热治疗的两大要素。通过构建纳米载体平台,PTT可协同增强其他治疗手段的疗效并降低不良反应。本文对OSCC的治疗现状、PTT的光热转换原理及在OSCC的治疗等方面进行综述,旨在为PTT在OSCC中的治疗提供理论依据。At present,the most clinically applied and researched treatments for oral squamous cell carcinoma(OSCC)mainly include surgery,radiotherapy,chemotherapy,traditional hyperthermia,gene therapy,immunotherapy,and photodynamic therapy.However,the therapeutic effect of these treatments is limited and often accompanied by varying degrees of side effects.Photothermal therapy(PTT)is a novel type of treatment method that can selectively kill cancer cells through photothermal effect with high safety.The two elements of PTT are near infrared with good tissue penetration and photothermal conversion agents with modifiability and selectivity.By building nanocarrier platforms,PTT can synergistically enhance the efficacy of other therapies and reduce their side effects.In this paper,the current treatment status of OSCC,the photothermal conversion principle of PTT,and its application in the treatment of OSCC were reviewed to provide a theoretical basis for the treatment of OSCC using PTT.

关 键 词：口腔鳞状细胞癌 光热治疗 光热效应 近红外光 光热转换剂 

分 类 号：R739.81[医药卫生—肿瘤]