唾液皮质醇、分泌型免疫球蛋白A水平在老年灼口综合征患者认知功能中的临床价值  

Clinical value of salivary cortisol and secretory immunoglobulin A levels in cognitive function of elderly patients with burning mouth syndrome

作　　者：童熹[1] 濮莉莉 吕辰翼 李国民[1] 王鹏程 TONG Xi;PU Lili;LYU Chenyi;LI Guomin;WANG Pengcheng(Department of Stomatology,Jinhua Municipal Central Hospital,Zhejiang Province,Jinhua 321000,China)

机构地区：[1]浙江省金华市中心医院口腔科,浙江金华321000

出　　处：《中国医药导报》2022年第16期98-101,共4页China Medical Herald

基　　金：浙江省中医药现代化专项项目(2021ZA007)。

摘　　要：目的探讨唾液皮质醇(Cor)、分泌型免疫球蛋白A(SIgA)水平对老年灼口综合征(BMS)患者认知功能的影响。方法选取2019年2月至2021年4月浙江省金华市中心医院(以下简称“我院”)收治的103例老年BMS患者为研究组,另选取我院同期体检健康的老年人54名为对照组,测定两组唾液Cor、SIgA水平及认知功能状况。将研究组按是否存在认知障碍分为认知障碍组(26例)和认知功能正常组(77例),比较两组临床资料,分析BMS患者发生认知障碍的影响因素及相关指标对其的预测价值。结果研究组Cor水平高于对照组,SIgA水平及简易精神状态检查、蒙特利尔认知评估量表评分均低于对照组(P<0.05)。认知功能障碍组的汉密尔顿抑郁量表(HAMD)评分及外周血Th2细胞、唾液Cor水平均高于认知功能正常组,外周血Th1细胞、唾液SIgA均低于认知功能正常组(P<0.05)。多因素分析结果显示,HAMD评分及唾液Cor、SIgA水平是BMS患者发生认知障碍的独立影响因素(P<0.05)。唾液Cor、SIgA联合诊断老年BMS患者发生认知功能障碍的受试者操作特征曲线下面积均高于二者单独诊断(P<0.05)。结论BMS患者唾液Cor、SlgA水平与神经功能有关,二者联合预测BMS患者认知功能具有一定效能,值得临床进一步研究。Objective To investigate the effects of salivary cortisol(Cor)and secretory immunoglobulin A(SIgA)levels on cognitive function in elderly patients with burning mouth syndrome(BMS).Methods A total of 103 elderly patients with BMS admitted to Jinhua Municipal Central Hospital,Zhejiang Province(hereinafter referred to as“our hospital”)from February 2019 to April 2021 were selected as the study group,and 54 healthy elderly people in our hospital during the same period were selected as the control group.The levels of salivary Cor,SIgA,and cognitive function of the two groups were determined.The study group was divided into cognitive impairment group(26 cases)and normal cognitive function group(77 cases)according to the existence of cognitive impairment.The clinical data of the two groups were compared to analyze the influencing factors of cognitive impairment in BMS patients and the predictive value of related indicators.Results Salivary Cor level in the study group was higher than that in the control group,salivary SIgA level,mini mental status examination,and Montreal cognitive assessment scale scores were lower than those in the control group(P<0.05).The scores of Hamilton depression(HAMD)scale,the levels of Th2 cells in peripheral blood,and salivary Cor in cognitive impairment group were higher than those in normal cognitive function group,while the levels of Th1 cells in peripheral blood and salivary SIgA were lower than those in normal cognitive function group(P<0.05).Multivariate analysis showed that HAMD score and salivary Cor,SIgA levels were independent influencing factors of cognitive impairment in BMS patients(P<0.05).The area under the receiver operating characteristic curve of Cor and SIgA combined diagnosis of cognitive dysfunction in elderly patients with BMS was higher than those of Cor and SIgA alone(P<0.05).Conclusion The levels of salivary Cor and SlgA of BMS patients are related to neurological function.The combination of the two has certain efficacy in predicting cognitive function of BMS pat

关 键 词：灼口综合征 皮质醇 分泌型免疫球蛋白A 认知功能 

分 类 号：R781.5[医药卫生—口腔医学]