丁螺环酮治疗精神分裂症阴性症状的效果及对认知功能的影响  

Effects of Buspirone in the treatment of negative symptoms of schizophrenia and its influence on cognitive function

作　　者：宋高峰 张成珍 姬祥利 SONG Gaofeng;ZHANG Chengzhen;JI Xiangli(Department of Psychiatry,Suzhou City Second People’s Hospital,Anhui Province,Suzhou 234000,China)

机构地区：[1]安徽省宿州市第二人民医院精神科,安徽宿州234000

出　　处：《中国医药导报》2022年第16期161-164,共4页China Medical Herald

基　　金：安徽省重点研究与开发计划项目(201904a07020048)。

摘　　要：目的探讨丁螺环酮治疗精神分裂症阴性症状的效果及对认知功能的影响。方法选取2020年2月至2021年2月安徽省宿州市第二人民医院收治的82例精神分裂症阴性症状患者,依照随机数字表法分为对照组和研究组,每组41例。对照组采用小剂量氨磺必利治疗,研究组采用小剂量氨磺必利联合丁螺环酮治疗。比较两组阳性与阴性症状量表(PANSS)评分、锥体外系副反应量表(RSESE)评分、临床疗效、认知功能(MMSE)评分,血清泌乳素(PRL)、睾酮(T)水平以及不良反应。结果治疗后,两组PANSS评分低于治疗前,且研究组低于对照组(P<0.05);两组RSESE评分高于治疗前,且研究组高于对照组(P<0.05);研究组临床疗效优于对照组(P<0.05);两组MMSE评分高于治疗前,且研究组高于对照组(P<0.05);两组血清PRL、T水平高于治疗前(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论丁螺环酮用于治疗精神分裂症阴性症状患者能够改善临床症状和认知功能,安全可靠。Objective To explore the effect of Buspirone on the treatment of negative symptoms of schizophrenia and its influence on cognitive function.Methods A total of 82 patients with negative symptoms of schizophrenia admitted to the Suzhou City Second People’s Hospital from February 2020 to February 2021 were selected.They were divided into control group and study group according to the random number table method.The control group was treated with low-dose Amisulpride,and the study group was treated with low-dose Amisulpride combined with Buspirone.Two groups of patients’positive and negative symptom scale(PANSS)score,extrapyramidal side effects scale(RSESE)score,clinical efficacy,cognitive function(MMSE)score,serum prolactin(PRL),testosterone(T)levels,and adverse reactions were compared.Results After treatment,PANSS scores in both groups were lower than those before treatment,and the study group was lower than the control group(P<0.05);RSESE scores of the two groups were higher than before treatment,and the study group was higher than the control group(P<0.05);the clinical efficacy of the study group was better than that of the control group(P<0.05);MMSE scores of the two groups were higher than those before treatment,and the study group was higher than the control group(P<0.05);serum PRL and T levels in both groups were higher than those before treatment(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Buspirone can improve clinical symptoms and cognitive function in patients with negative symptoms of schizophrenia,and is safe and reliable.

关 键 词：小剂量 氨磺必利 丁螺环酮 精神分裂症 阴性症状 认知功能 

分 类 号：R749[医药卫生—神经病学与精神病学]