不同临床特征甲状腺乳头状癌患者BRAFV600E基因突变情况及其中央区颈部淋巴结转移的影响因素  

BRAFV600E gene mutation in patients with thyroid papillary carcinoma with different clinical characteristics and its influencing factors of central cervical lymph node metastasis

在线阅读下载全文

作  者:徐坤[1] 党静[1] 张晓敏[1] XU Kun;DANG Jing;ZHANG Xiaomin(Department of Geriatrics,the Second Hospital of Lanzhou University,Gansu Province,Lanzhou 730030,China)

机构地区:[1]兰州大学第二医院老年病科,甘肃兰州730030

出  处:《中国当代医药》2022年第18期77-79,83,共4页China Modern Medicine

摘  要:目的探讨不同临床特征甲状腺乳头状癌(PTC)患者BRAFV600E基因突变情况及其中央区颈部淋巴结转移的影响因素。方法选取2019年6月至2021年12月兰州大学第二医院老年病科收治的PTC患者80例为研究对象,制备标本测定BRAFV600E基因是否发生突变。分析不同临床病理特征PTC患者的BRAFV600E基因突变情况、分析中央区颈部淋巴结转移与BRAFV600E基因突变间的关系及相关影响因素。结果依据是否发生BRAFV600E基因突变将患者分为阳性组(n=38),阴性组(n=42)。阳性组肿瘤大小大于阴性组,多灶性肿瘤、包膜外侵、中央区淋巴结转移、单侧淋巴结转移数均高于阴性组,差异有统计学意义(P<0.05);依据中央区颈部淋巴结是否转移分为转移组(n=20)及无转移组(n=9)。转移组肿瘤大小大于无转移组,双侧肿瘤、多灶性肿瘤、包膜侵犯、BRAF基因转移发生率均高于无转移组,差异有统计学意义(P<0.05)。多因素logistic分析显示,多灶性肿瘤、包膜侵犯、BRAFV600E基因突变是PTC中央区颈部淋巴结转移的独立危险因素(P<0.05)。结论PTC肿瘤大小、多灶性肿瘤、包膜侵犯、BRAFV600E基因突变等均可有效预测中央区颈部淋巴结转移,在手术方案制定中需注意预防性地行中央区淋巴结清扫。Objective To investigate the mutation of BRAFV600E gene in patients with thyroid papillary carcinoma(PTC)with different clinical characteristics and the influencing factors of central cervical lymph node metastasis.Methods A total of 80 PTC patients admitted to the Department of Geriatrics,the Second Hospital of Lanzhou University from June 2019 to December 2021 were selected as the research subjects,samples were prepared to determine whether BRAFV600E gene mutation occurred.The BRAFV600E gene mutations in PTC patients with different clinicopathological characteristics were analyzed,and the relationship between central cervical lymph node metastasis and BRAFV600E gene mutations and related influencing factors were analyzed.Results Patients were divided into positive group(n=38)and negative group(n=42)according to whether BRAFV600E gene mutation occurred.The tumor size in the positive group was larger than that in the negative group,and the number of multifocal tumors,envelope invasion,central lymph node metastasis and unilateral lymph node metastasis in the positive group were higher than those in the negative group,the differences were statistically significant(P<0.05).According to whether the cervical lymph nodes in the central region metastasized,they were divided into metastasis group(n=20)and non metastasis group(n=9).The tumor size in the metastasis group was larger than that in the non metastasis group,and the incidence of bilateral tumors,multifocal tumors,capsule invasion and BRAF gene metastasis were higher than those in the non metastasis group,the differences were statistically significant(P<0.05).Multivariate logistic analysis showed that multifocal tumor,envelope invasion and BRAFV600E gene mutation were independent risk factors for cervical lymph node metastasis in the central region of PTC(P<0.05).Conclusion PTC tumor size,multifocal tumor,envelope invasion and BRAFV600E gene mutation can effectively predict central cervical lymph node metastasis.Preventive central lymph node dissection should be

关 键 词:甲状腺乳头状癌 中央区颈部淋巴结转移 BRAFV600E基因突变 影响因素 

分 类 号:R736.1[医药卫生—肿瘤]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象