沉默信息调节蛋白3在日光性角化病和皮肤鳞状细胞癌中的表达及意义  

Expression of Silent Information Regulator Protein-3 in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma

作　　者：郭美亮 刘婉雯 孟琴琴 袁定芬[1] 邓辉[1] Guo Meilaing;Liu Wanwen;Meng Qinqin;Yuan Dingfen;Deng Hui(Shanghai Jiaotong University Affiliated Sixth People's Hospital,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院,上海200233

出　　处：《中国中西医结合皮肤性病学杂志》2022年第3期211-214,共4页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(编号:81673054)。

摘　　要：目的比较沉默信息调节蛋白3(SIRT3)在正常皮肤(NS)、日光性角化病(AK)和皮肤鳞状细胞癌(cSCC)组织中的表达情况。方法通过免疫组化SABC法检测30例NS、30例AK和28例cSCC组织标本中的SIRT3表达。结果SIRT3在cSCC组中阳性细胞率为(60.27%±17.90)%,显著高于NS组(40.99%±14.98)%和AK组(45.31%±12.66)%。SIRT3的阳性细胞率在NS组和AK组之间的差异无统计学意义。SIRT3在NS、AK和cSCC组织中染色强阳性率分别为13.33%(4/30)、26.67%(8/12)和42.86%(12/28),cSCC组与NS组的差异有统计学意义(P<0.05)。结论SIRT3的高表达可能与cSCC的发病机制相关。Objective In order to compare the expression levels of silent information regulator protein-3(SIRT3) in normal skin(NS),actinic keratosis(AK) and cutaneous squamous cell carcinoma(cSCC). Methods SIRT3 was detected by immunohistochemical strept avidin-biotin complex(SABC) method in 30 cases of NS,30 cases of AK and 28 cases of cSCC.Results The positive rate of SIRT3 in cSCC group was(45.31±12.66)%,which was significantly higher than that in NS group(40.99±14.98)% and AK group(60.27±17.90)%. There were no significant differences in SIRT3 positive cell rate between NS group and AK group. The strong positive rates of SIRT3 in NS,AK and cSCC tissues were 13.33%(4/30),26.67%(8/12) and 42.86%(12/28),respectively. There were significant differences between cSCC group and NS group(P<0.05).Conclusion The high expression of SIRT3 may be related to the pathogenesis of cSCC.

关 键 词：沉默信息调节蛋白3 日光性角化病 皮肤鳞状细胞癌 

分 类 号：R739.5[医药卫生—肿瘤]