不同胃黏膜病变中livin、survivin、Pak-1和caspase-7的表达及其意义  

Expressions and Significance of Livin,Survivin,Pak-1 and Caspase-7 in Different Gastric Mucosal Lesions

作　　者：姜姝羽 任丽梅[2] 武金宝[2] 娄佳欣 苏琪皓 刘小芳 JIANG Shuyu;REN Limei;WU Jinbao;LOU Jiaxin;SU Qihao;LIU Xiaofang(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia,014040;Department of Gastroenterology,the Second Affiliated Hospital of Baotou Medical College,Baotou,Inner Mongolia)

机构地区：[1]内蒙古科技大学包头医学院,014040 [2]包头医学院第二附属医院消化内科

出　　处：《胃肠病学》2021年第8期481-485,共5页Chinese Journal of Gastroenterology

摘　　要：背景:Livin、survivin和Pak-1均与胃癌发生、发展有关,livin和survivin通过抑制caspase-7的活性发挥作用。目的:观察不同胃黏膜病变中livin、survivin、Pak-1和caspase-7的表达及其意义。方法:收集2015年1月-2019年12月包头医学院第二附属医院45例胃癌及其癌旁组织、45例慢性萎缩性胃炎伴肠化生、45例慢性非萎缩性胃炎组织。以免疫组化染色法检测livin、survivin、Pak-1和caspase-7表达,并分析其与胃癌患者临床病理特征的关系。结果:与慢性非萎缩性胃炎组和癌旁组相比,肠化生组livin、survivin、Pak-1的阳性表达率显著升高(P<0.05),caspase-7显著降低(P<0.05)。与肠化生组相比,胃癌组livin、survivin、Pak-1的阳性表达率显著升高(P<0.05),caspase-7显著降低(P<0.05)。Livin、survivin、Pak-1和caspase-7表达与胃癌的分化程度、TNM分期、浸润深度和淋巴结转移密切相关(P<0.05)。结论:Livin、survivin、Pak-1和caspase-7在胃癌发生、发展中均起重要作用。Background: Livin, survivin and Pak-1 are all related to the occurrence and development of gastric cancer. Livin and survivin play their roles by inhibiting the activity of caspase-7. Aims: To investigate the expressions and significance of livin, survivin, Pak-1 and caspase-7 in different gastric mucosal lesions. Methods: A total of 45 cases of gastric cancer and paracancerous tissue, 45 chronic atrophic gastritis with intestinal metaplasia, 45 chronic non-atrophic gastritis from Jan. 2015 to Dec. 2019 at the Second Affiliated Hospital of Baotou Medical College were collected. Immunohistochemistry was used to detect the expressions of livin, survivin, Pak-1 and caspase-7, and their correlations with clinicopathological features of gastric cancer patients were analyzed. Results: Compared with chronic non-atrophic gastritis group and paracancerous group, the positivity expression rates of livin, survivin and Pak-1 in intestinal metaplasia group were significantly increased(P<0.05), while caspase-7 was significantly decreased(P<0.05). Compared with intestinal metaplasia group, the positivity expression rates of livin, survivin and Pak-1 in gastric cancer group were significantly increased(P<0.05), while caspase-7 was significantly decreased(P<0.05). Expressions of livin, survivin, Pak-1 and caspase-7 were correlated with the differentiation degree, TNM stage, depth of infiltration and lymph node metastasis in patients with gastric cancer(P<0.05). Conclusions: Livin, survivin, Pak-1 and caspase-7 play important roles in the occurrence and development of gastric cancer.

关 键 词：LIVIN SURVIVIN Pak-1 CASPASE-7 胃肿瘤 免疫组织化学 

分 类 号：R73[医药卫生—肿瘤]