肉苁蓉联合复方左旋多巴对改善便秘及肠道菌群的影响观察  

Effect of Cistanche combined with compound levodopa on constipation and intestinal flora in patients with Parkinson’s disease

作　　者：孙永奇 胡运新 曾昭龙 符振发 Sun Yongqi;Hu Yunxin;Zeng Zhaolong(Department of Neurology,Guangdong 999 Brain Hospital,Guangzhou 510510,China)

机构地区：[1]广东三九脑科医院内六科,广州510510

出　　处：《中华保健医学杂志》2022年第3期215-217,共3页Chinese Journal of Health Care and Medicine

基　　金：广州市科技计划项目(202102080506)。

摘　　要：目的探究肉苁蓉联合复方左旋多巴对帕金森患者非运动症状的改善效果并分析其对患者肠道菌群的影响。方法前瞻选取广东三九脑科医院2021年1月~6月收治的80例帕金森患者,将其按随机数表法分为观察组和对照组,每组40例,对照组以复方左旋多巴治疗,观察组在对照组基础上联合使用肉苁蓉治疗,比较两组接受治疗后的非运动症状情况以及肠道菌群水平。结果观察组接受治疗后2、4个月时的非运动症状量表(NMSS)评分均显著降低,且低于对照组,差异有统计学意义(P<0.05);观察组接受治疗后2、4个月时的便秘严重度评分量表(CSS)评分均显著降低,对照组接受治疗后4个月时的评分显著增高,差异有统计学意义(P<0.05);接受治疗后,观察组肠道双歧杆菌、乳酸杆菌以及普拉梭菌水平显著降低,肠杆菌水平显著增高,对照组肠道双歧杆菌、乳酸杆菌以及普拉梭菌水平显著增高,肠杆菌水平显著降低,两组各肠道菌水平差异有统计学意义(P<0.05)。结论肉苁蓉联合复方左旋多巴治疗帕金森患者可以调节肠道菌群,有效改善便秘等非运动症状。Objective To explore the effects of Cistanche combined with compound levodopa on non-motor symptoms and intestinal flora of patients with Parkinson’s disease.Methods Eighty patients with Parkinson’s disease who were admitted to Guangdong Sanjiu Brain Hospital between January 2021 to June 2021 They were divided into observation group and control group according to the random number table method,with 40 cases in each group.Patients in the control group were treated with compound levodopa,and patients in the observation group were treated with Cistanche on this basis.Non-motor symptoms and intestinal flora of the 2 groups were compared.Results The NMSS scores of observation group were significantly reduced at 2 and 4 months after treatment,and were lower than those of the control group(P<0.05).The CSS scores of observation group were significantly reduced at2 and 4 months after treatment(P<0.05),but the CSS score of control group was significantly increased at 4 months after treatment(P<0.05).After treatment,the levels of intestinal bifidobacteria,lactobacilli,and Faecalibacterium prausnitzii were reduced,and the level of enterobacteria was significantly increased in the observation group(P<0.05).However,the levels of intestinal bifidobacteria,lactobacilli,and Faecalibacterium prausnitzii were significantly increased,and the level of enterobacteria was significantly reduced in the control group(P<0.05).The levels of intestinal bacteria showed statistically significant differences between the 2 groups after treatment(P<0.05).Conclusion Cistanche combined with compound levodopa can regulate intestinal flora and effectively improve non-motor symptoms like constipation in patients with Parkinson’s disease.

关 键 词：帕金森 非运动症状 肠道菌群 肉苁蓉 左旋多巴 

分 类 号：R574[医药卫生—消化系统]