一种可检测神经性毒剂的新型比色探针  

A novel colorimetric probe for nerve agent detection

作　　者：张鑫月 岑金凤 石桂炎 白云 李明珠 孙铭学 肖凯 王先友[1] 孟文琪 ZHANG Xinyue;CEN Jinfeng;SHI Guiyan;BAI yun;LI Mingzhu;SUN Mingxue;XIAO Kai;WANG Xianyou;MENG Wenqi(School of Pharmacy,Henan University,Kaifeng 475004,China;Department of Naval Medicine,Naval Medical University,Shanghai 200433,China)

机构地区：[1]河南大学药学院,开封475004 [2]海军军医大学海军医学系,上海200433

出　　处：《分析试验室》2022年第6期643-647,共5页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金项目(81801869);上海市公共卫生优秀青年人才项目(GWV-10.2-YQ18);上海市自然科学基金项目(21ZR1477700);海军医学系青年人才培育课题培育计划项目(HL20JD2507)资助。

摘　　要：从实验室自建的化合物库中筛选出2个可检测神经毒剂的比色探针Z1,Z2。紫外光谱实验表明Z1,Z2的紫外吸收波长分别为424,446 nm;加入神经性毒剂模拟剂后,Z1,Z2的紫外吸收波长分别红移至556,542 nm,在3 s以内观察到颜色的显著变化,可实现裸眼识别,2 min内可完全反应。回收率实验表明探针Z1,Z2可以定量检测神经毒剂,Z1的检出限为0.57μmol/L。可将Z1制备成检测试纸用于神经性毒剂梭曼的快速检测。与制式的检测试纸FZZ01相比,Z1试纸具有灵敏度高、变色显著的优势。Based on the self-built compound library,two colorimetric probes named Z1 and Z2 were screened out.In the ultraviolet spectrum experiment,the maximum absorption wavelengths of Z1 and Z2 were 424 nm and 446 nm,respectively.After the addition of nerve agent mimics,the maximum absorption wavelengths of Z1 and Z2 were red shifted to 556 nm and 542 nm respectively,accompanied by significant color changes within 3 s,which could be recognized by naked eye,and the reaction can be fully completed within 2 min.The recovery experiments showed that the probes Z1 and Z2 could detect nerve agents quantitatively and the limit of detection of Z1 for nerve agent was 0.57 μmol/L.Z1 was prepared into test paper for rapid on-site detection of nerve agent.Compared with standard test paper FZZ01,the test paper of Z1 showed obvious advantages of high sensitivity and significant discoloration.

关 键 词：神经毒剂 探针 比色识别 

分 类 号：O657.3[理学—分析化学]