胃食管反流病患者胃食管连接部形态与24 h食管pH-阻抗监测结果、胃镜结果的相关性研究  

Correlation of gastroesophageal junction morphology with results of 24-h esophageal pH impedance monitoring and gastroscopy in patients with gastroesophageal reflux disease

作　　者：王银萍 季峰[1] 张永乐[1] Wang Yinping;Ji Feng;Zhang Yongle(Department of Gastroenterology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院消化内科,450000

出　　处：《中国实用医刊》2022年第6期26-29,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析胃食管反流病患者胃食管连接部形态与24 h食管pH-阻抗监测结果、胃镜结果的相关性。方法抽取2020年10月至2021年10月在郑州大学第一附属医院接受治疗的80例胃食管反流病患者为研究对象,所有患者均接受食管高分辨测压、胃镜检查以及24 h食管pH-阻抗监测。根据食管高分辨测压结果对胃食管反流病患者的胃食管连接部形态进行分型,其中胃食管连接部形态Ⅰ型(A组)30例,Ⅱ型(B组)28例,Ⅲ型(C组)22例。分析三组患者胃镜检查结果(食管炎发生情况及分级)以及24 h食管pH-阻抗监测结果。结果 C组食管炎发生率、LA-B级及以上占比高于A、B两组(P<0.05);B组食管炎发生率、LA-B级及以上占比高于A组(P<0.05);三组患者气体反流次数、非酸反流次数比较差异未见统计学意义(P>0.05);A、B组24 h食管pH-阻抗监测结果比较(P>0.05);C组液体反流次数低于A、B组(P<0.05);C组酸反流次数、DcMeester评分以及酸碱暴露时间高于A、B组(P<0.05)。结论胃食管反流病患者中,胃食管连接部形态为Ⅲ型者DcMeester评分、酸碱暴露时间、反流次数以及食管炎发生率高于胃食管连接部形态为Ⅰ、Ⅱ型者。Objective To analyze the correlation of the morphology of gastroesophageal junction with results of 24-h esophageal pH impedance monitoring and gastroscopy in patients with gastroesophageal reflux disease.Methods Eighty patients with gastroesophageal reflux disease treated in the First Affiliated Hospital of Zhengzhou University from October 2020 to October 2021 were selected as research object.All patients underwent esophageal high-resolution manometry,gastroscopy and 24-h esophageal pH impedance monitoring.According to the results of esophageal high-resolution manometry,the morphology of gastroesophageal junction in patients with gastroesophageal reflux disease was classified.Among the 80 patients,there were 30 cases of gastroesophageal junction typeⅠ(group A),28 cases of typeⅡ(group B)and 22 cases of typeⅢ(group C).The results of gastroscopy(occurrence and grading of esophagitis)and 24-h esophageal pH impedance monitoring were analyzed.Results The incidence of esophagitis and the proportion of equal or over LA-B stage in group C were significantly higher than those in group A and group B(P<0.05);the incidence of esophagitis and the proportion of equal or over LA-B stage in group B were significantly higher than those in group A(P<0.05);there was no significant difference in the frequency of gas reflux and non acid reflux among the three groups(P>0.05);there was no significant difference in comparison of 24-h esophageal pH impedance monitoring results between group A and group B(P>0.05);the frequency of fluid reflux in group C was lower than that in group A and group B(P<0.05).The frequency of acid reflux,DcMeester score and acid-base exposure time in group C were higher than those in group A and group B(P<0.05).Conclusions In patients with gastroesophageal reflux disease,the DcMeester score,acid-base exposure time,reflux times and incidence of esophagitis in patients with gastroesophageal junction morphology of typeⅢare higher than those in patients with gastroesophageal junction morphology of typeⅠa

关 键 词：胃食管反流 24 h食管pH-阻抗监测 胃镜 胃食管连接部形态 

分 类 号：R571[医药卫生—消化系统]