CO_(2)激光联合低温等离子射频消融术治疗累及前联合早期声门型喉癌临床观察  

Clinical observation of CO_(2) laser beam and low-temperature radiofrequency ablation in treating the early glottic cancer involved with anterior commissure

作　　者：牛广宪[1] 苏磊[1] 苗伟震 NIU Guangxian;SU Lei;MIAO Weizhen(Department of Otolaryngology,Puyang Oilfield General Hospital,Puyang Henan 457001,China)

机构地区：[1]濮阳市油田总医院耳鼻喉科,河南濮阳457001

出　　处：《临床研究》2022年第7期15-18,共4页Clinical Research

摘　　要：目的分析CO_(2)激光加低温等离子射频消融对累及前联合声门型喉癌早期的疗效。方法选取2019年1月至2021年5月濮阳市油田总医院收治的累及前联合声门型喉癌早期患者共102例进行研究,依据随机数字表法分成对照组(CO_(2)激光)和观察组(在对照组基础上加以低温等离子射频消融术),各51例,比较两组在不同治疗方案下的手术时间、术中失血量、术后疼痛得分及声带黏度恢复得分;术前及术后3个月的组基频、基频微扰、谐噪比和振幅微扰等嗓音恢复指标;术后对两组进行1年随访,统计两组的复发率。结果观察组手术时间长于对照组,声带黏度恢复得分低于对照组,差异有统计学意义(P<0.05);两组术中失血量、术后疼痛得分相比,差异无统计学意义(P>0.05)。术前,两组基频、基频微扰、谐噪比及振幅微扰相比,差异无统计学意义(P>0.05);术后3个月,观察组的基频、基频微扰及振幅微扰低于对照组,谐噪比高于对照组,差异有统计学意义(P<0.05)。观察组术后3个月的复发率低于对照组,差异有统计学意义(P<0.05)。结论CO_(2)激光加低温等离子射频消融对累及前联合声门型喉癌早期患者疗效确切,能促进其声带黏膜恢复,改善其嗓音,降低其复发率。Objective To analyze the clinical value of CO_(2) laser beam and low-temperature radiofrequency ablation in treating the early glottic cancer involved with anterior commissure.Methods 102 early glottic cancer patients involved with anterior commissure treated from January 2019 to May 2021 in our hospital were selected.According to random number table,patients were divided into control group(N=51,CO_(2) laser beam)and observation group(N=51,CO_(2) laser beam and low-temperature radiofrequency ablation).Group contrast results were obtained through the operation time,intraoperative bleeding volume,pain scores,vocal mucosal recovery scores,voice recovery indicators like fundamental frequency,fundamental frequency perturbation,harmonic to noise ratio and amplitude perturbation before surgery and after 3 months of surgery as well as recurrence rate during one-year follow-up visit.Results The operation time in the observation group was longer than control group;the mucosal recovery scores were lower than control group(P<0.05);the intraoperative bleeding volume and pain scores between groups were not significantly different(P>0.05);before surgery,there were no significant between-group differences about the fundamental frequency,fundamental frequency perturbation,harmonic to noise ratio and amplitude perturbation(P>0.05);after 3 months of surgery,the fundamental frequency,fundamental frequency perturbation and amplitude perturbation in the observation group were lower than control group;the harmonic to noise ratio was higher than control group(P<0.05);after 3 months of surgery,the recurrence rate in the observation group was lower than control group(P<0.05).Conclusion CO_(2) laser beam and low-temperature radiofrequency ablation can promote the vocal mucosal recovery,improve the patient’s voice and reduce the surgical recurrence rate.It is worthy of clinical application.

关 键 词：声门型喉癌 前联合 CO_(2)激光 低温等离子射频消融术 复发率 

分 类 号：R739.65[医药卫生—肿瘤]