影响颈段食管癌放疗患者预后的相关因素分析  

Analysis of related factors influencing the prognosis of patients with cervical esophageal cancer after radiotherapy

作　　者：冯活林 肖剑 黄锡英 赖超 FENG Huolin;XIAO Jian;HUANG Xiying;LAI Chao(No.1 Oncology Department,Maoming Hospital of Traditional Chinese Medicine,Maoming 525000,China)

机构地区：[1]茂名市中医院肿瘤一科,广东茂名525000

出　　处：《临床医学研究与实践》2022年第19期32-34,42,共4页Clinical Research and Practice

摘　　要：目的分析影响颈段食管癌放疗患者预后的相关因素。方法选择我院2015年1月至2018年2月收治的68例颈段食管癌患者作为研究对象,所有患者均接受三维适形放疗治疗,分析患者的近期疗效、不良反应发生情况,并通过Cox风险比例回归模型分析影响放疗后3年生存率、无进展生存率的相关因素。结果放疗治疗后,患者的治疗总有效率为95.59%,不良反应总发生率为73.53%,放疗后3年生存率为55.88%,放疗后3年无进展生存率为47.06%。Cox风险比例回归模型分析结果显示,年龄、临床TNM分期、肿瘤靶区体积(GTV)是影响患者放疗后3年生存率的独立危险因素,病变长度、临床TNM分期、GTV及照射方式是影响患者放疗后3年无进展生存率的独立危险因素(P<0.05)。结论选择性淋巴结区域照射(ENI)是颈段食管癌放疗患者的首选方式,能够有效提高患者的无进展生存率及生存率;同时,年龄、临床TNM分期、GTV是影响患者放疗后3年生存率的独立危险因素,病变长度、临床TNM分期、GTV以及照射方式是影响患者放疗后3年无进展生存率的独立危险因素。Objective To analyze the related factors influencing the prognosis of patients with cervical esophageal cancer after radiotherapy. Methods A total of 68 patients with cervical esophageal cancer treated in our hospital from January2015 to February 2018 were selected as the research objects. All patients received three-dimensional conformal radiotherapy. The short-term effect and occurrence of adverse reactions of the patients were analyzed, and the related factors affecting the 3-year survival rate and progression free survival rate after radiotherapy were analyzed by Cox risk proportional regression model. Results After radiotherapy, the total effective rate of treatment of patients was 95.59%, the total incidence of adverse reactions was 73.53%, the 3-year survival rate after radiotherapy was 55.88%, and the 3-year progression free survival rate after radiotherapy was 47.06%. Cox risk proportional regression model analysis results showed that age, clinical TNM stage and gross tumor volume(GTV) were independent risk factors affecting the 3-year survival rate after radiotherapy, while lesion length, clinical TNM stage, GTV and irradiation mode were independent risk factors affecting the 3-year progression free survival rate after radiotherapy(P<0.05). Conclusion Elective nodal irradiation(ENI) is the first choice for patients with cervical esophageal cancer for radiotherapy, which can effectively improve the progression free survival rate and survival rate. At the same time, age, clinical TNM stage and GTV are independent risk factors affecting the 3-year survival rate of patients after radiotherapy, and lesion length, clinical TNM stage, GTV and irradiation mode are independent risk factors affecting the 3-year progression free survival rate of patients after radiotherapy.

关 键 词：颈段食管癌 放疗 选择性淋巴结区域照射 

分 类 号：R735.1[医药卫生—肿瘤]