翼状胬肉相关致病因子的研究进展  

Review of factors in pterygium pathology

作　　者：陈杨[1] 魏超群 弥禹 葛红岩[1] Yang Chen;Chao-Qun Wei;Yu Mi;Hong-Yan Ge(Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China)

机构地区：[1]哈尔滨医科大学附属第一医院眼科医院,中国黑龙江省哈尔滨市150001

出　　处：《国际眼科杂志》2022年第7期1133-1136,共4页International Eye Science

摘　　要：翼状胬肉(ptergium)是在多种因素和因子的共同作用下形成的眼表疾病,主要的发病机制与紫外线照射及辐射后所引起的一系列改变有关,具体过程至今仍不明确。血管内皮生长因子(VEGF)升高、炎症反应加重、新生血管的产生、氧化应激反应、上皮-间质细胞转化(EMT)、抑癌基因失活等是目前公认的翼状胬肉发病的原因,但各个因素及因子的具体作用过程仍有待研究。探究其具体相关因素及其在翼状胬肉发病过程中的作用,有助于为临床诊治提供靶向治疗方案及有效预防措施。Pterygium is an ocular surface disease formed by many factors and associate with a series of changes caused by ultraviolet irradiation and radiation,its pathogenesis is still uncertain.Elevated vascular endothelial growth factor(VEGF),inflammatory infiltrates,angiogenesis,oxidative stress,epithelial-mesenchymal cell transition(EMT),and tumor suppressor gene inactivation are currently recognized causes of pterygium.The mechanism of this factor in pterygium deveopment is still not completely understood.This review aimed to investigate the role of these factors in pterygium formation and provide targeted therapy and effective preventive measures for clinical diagnosis and treatment.

关 键 词：翼状胬肉 上皮-间质细胞转化 血管内皮生长因子 转化生长因子-Β P53 

分 类 号：R73[医药卫生—肿瘤]