MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography  

作　　者：Xiaodong Sun Bing Niu Qi Zhang Qin Chen 

机构地区：[1]School of Medicine,Shanghai University,Shanghai,200444,China [2]School of Life Sciences,Shanghai University,Shanghai,200444,China [3]School of Pharmacy,Jiangsu University,Zhenjiang,Jiangsu,212013,China

出　　处：《Journal of Pharmaceutical Analysis》2022年第3期509-516,共8页药物分析学报（英文版）

基　　金：funded by the National Natural Science Foundation of China(Grant No.:82003705).

摘　　要：Homochiral metal-organic frameworks(MOFs)have attracted considerable attention in many fields of research,such as chiral catalysis and chiral chromatography.However,only few homochiral MOFs can be effectively used in capillary electrochromatography(CEC)and their performances are far from adequate.In this study,we successfully synthesized achiral nanocrystalline MIL-53.A facile post-synthetic modification strategy was then implemented to functionalize the product,yielding a homochiral MOF:L-His-NH-MIL-53.This MOF was then employed as a chiral coating in open-tubular CEC mode(OT-CEC),and,as such,it exhibited high enantioselectivities for several racemic drugs.The homochiral MOF and the fabricated capillary coating were systematically characterized using transmission electron microscopy,scanning electron microscopy(with energy-dispersive X-ray spectrometry),Fourier-transform infrared spectroscopy,X-ray diffractometry,thermogravimetric analysis,circular dichroism spectroscopy,Brunauer-Emmett-Teller surface area measurements,and X-ray photoelectron spectroscopy.This study is expected to provide a new strategy for the design and establishment of MOF-based chiral OT-CEC systems.

关 键 词：Homochiral MOF L-His-NH-MIL-53 Chiral stationary phase Capillary electrochromatography ENANTIOSEPARATION 

分 类 号：R318[医药卫生—生物医学工程]