不同剂量氯胺酮与赛拉嗪复合用于巴马小型猪短时间麻醉效果观察  

Comparison of the Anesthetic Effects of Different Doses of Ketamine Hydrochloride Combined Xylazine on Short-term Anesthesia in Bama Miniature Pigs

作　　者：申晨 张宝杰[1] 王学民 朱瑾彦 张敏[1] 李彬[1] SHEN Chen;ZHANG Baojie;WANG Xuemin;ZHU jinyan;ZHANG Min;LI Bin(Center for Cardiovascular Experimental Study and Evaluation of Fuwai Hospital,Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials,Animal Experimental Centre,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 102308,China)

机构地区：[1]中国医学科学院北京协和医学院阜外医院心血管在体实验研究与评价中心,心血管植入材料临床前研究与评价北京市重点实验室,动物实验中心,北京102308

出　　处：《实验动物与比较医学》2022年第3期262-265,共4页Laboratory Animal and Comparative Medicine

摘　　要：目的对小型猪行盐酸氯胺酮及赛拉嗪复合麻醉,并分析药物剂量高低对麻醉效果的影响。方法将36头巴马小型猪随机分为3组:A组应用氯胺酮10 mg/kg+赛拉嗪2 mg/kg行肌内注射麻醉;B组应用氯胺酮10 mg/kg+赛拉嗪1.5 mg/kg行肌内注射麻醉;C组应用氯胺酮5 mg/kg+赛拉嗪2 mg/kg行肌内注射,然后记录麻醉监测指标。结果A组及B两组之间麻醉起效时间和清醒时间均无明显差异(P>0.05),A组及B组麻醉清醒时间明显长于C组(P<0.05)。结论应用氯胺酮10 mg/kg复合赛拉嗪1.5~2 mg/kg肌内注射麻醉,起效较快,麻醉深度稳定,体动不明显,安全性满意,可应用于短时间的手术和诊疗处置。Objectives To perform the combined anesthesia of ketamine hydrochloride and xylazine in miniature pigs,and to analyze the effect of drug dose on anesthesia.Methods Thirty-six Bama miniature pigs were randomly divided into three groups.Group A was administered with ketamine hydrochloride(10 mg/kg)+xylazine(2 mg/kg).Group B was administered with ketamine hydrochloride(10 mg/kg)+xylazine(1.5 mg/kg).Group C was administered with ketamine hydrochloride(5 mg/kg)+xylazine(2 mg/kg),and anesthesia monitoring indexes were recorded.Results There were no significant differences in anesthesia onset time and awake time between groups A and B(P>0.05),and the awake time of anesthesia in groups A and B was significantly longer than that in group C(P<0.05).Conclusion Ketamine hydrochloride(10 mg/kg)combined with xylazine(1.5‒2 mg/kg)anesthesia has a rapid effect,stable anesthesia depth,no obvious movement,and satisfactory safety.It can be used in short procedures,diagnoses,and treatments.

关 键 词：氯胺酮 赛拉嗪 巴马小型猪 复合麻醉 

分 类 号：Q95-33[生物学—动物学] R-332[医药卫生]