铁死亡在多形性胶质母细胞瘤治疗中的研究进展  

Research progress of ferroptosis in treatment of glioblastoma multiforme

作　　者：斯宝 张刚利[1] 胡昌辰[1] SI Bao;ZHANG Gangli;HU Changchen(Neurosurgery Department,the Fifth Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi,030000)

机构地区：[1]山西医科大学第五临床医学院神经外科,山西太原030000

出　　处：《实用临床医药杂志》2022年第12期125-130,共6页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(30901774);山西省基础研究项目自然科学项目(20140110382);山西省重点研发计划(指南)项目(201803D421055)。

摘　　要：多形性胶质母细胞瘤(GBM)属于Ⅳ级胶质瘤,是成人最常见的原发性恶性脑肿瘤之一。胶质瘤干细胞有极高的恶性程度,对放化疗具有强耐受性。本文对细胞铁死亡与GBM相关机制进行综述,并探讨干预和治疗GBM的前景。Glioblastoma multiforme(GBM) is stage IV glioma,and is one of the most common primary malignant brain tumors in adults. Glioma stem cells have strong tolerance to chemoradiotherapy and high malignancy.This review summarized the mechanism of ferroptosis and GBM,and explored its prospects in intervention and treatment of GBM.

关 键 词：多形性胶质母细胞瘤 细胞铁死亡 干预 治疗 恶性程度 

分 类 号：R739.41[医药卫生—肿瘤] R730.5[医药卫生—临床医学]