血清表皮生长因子和C反应蛋白与精神分裂症患者认知功能的关系  

Correlations of serum epidermal growth factor and C-reactive protein with cognitive function in patients with schizophrenia

作　　者：张玥 唐小伟 肖文焕 赵小亚 ZHANG Yue;TANG Xiaowei;XIAO Wenhuan;ZHAO Xiaoya(Department of Psychiatry,Yangzhou Wutaishan Hospital of Jiangsu Province,Yangzhou,Jiangsu,225003)

机构地区：[1]江苏省扬州五台山医院精神科,江苏扬州225003

出　　处：《实用临床医药杂志》2022年第11期76-80,86,共6页Journal of Clinical Medicine in Practice

基　　金：江苏省卫生健康委面上项目(M2020031);江苏省扬州市科技计划项目(YZ2020104,YZ2020109);江苏省扬州市“十三五”科教强卫专项经费资助项目(ZDRC201830);江苏省扬州五台山医院2020年度院课题项目(WTS2020002,WTS2020012)。

摘　　要：目的探讨精神分裂症患者血清表皮生长因子(EGF)、C反应蛋白(CRP)及其交互作用与认知功能的关系。方法招募符合美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)精神分裂症诊断标准的117例患者作为研究对象,采用阳性和阴性症状量表(PANSS)、神经心理状态成套量表(RBANS)分别评估患者的精神症状和认知功能。采用酶联免疫吸附试验(ELISA)法、免疫比浊法分别检测患者的血清EGF、CRP浓度。采用相关性分析和分层回归分析探讨EGF、CRP和认知功能之间的关系。结果相关性分析结果显示,EGF与CRP呈显著负相关(r=-0.550,P<0.001);分层回归分析结果显示,EGF和CRP交互项(β=0.411,t=4.436,P<0.001)可以正向预测视觉广度,使加入该交互项的新模型(R^(2)=0.209)的预测能力较原模型增加了0.146,说明该交互项可以解释视觉广度变化的14.6%。结论CRP和EGF之间的交互作用可能与精神分裂症患者认知功能有关,这有利于探索精神分裂症认知缺陷的客观标记物。Objective To investigate the relationships of serum epidermal growth factor(EGF),C-reactive protein(CRP)and their interactions with cognitive function in patients with schizophrenia.Methods According to the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-Ⅳ)for schizophrenia,117 patients were recruited in this study.Patients'mental symptoms and cognitive function were assessed using the Positive and Negative Symptom Scale(PANSS)and Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Enzyme-linked immunosorbent assay(ELISA)and immunoturbidimetric method were used to detect the serum concentrations of EGF and CRP,respectively.The correlations of EGF and CRP with cognitive function were explored using correlation and hierarchical regression analysis.Results Correlation analysis showed that EGF was significantly negatively correlated with CRP(r=-0.550,P<0.001).hierarchical regression results showed that the interaction terms of EGF and CRP(β=0.411,t=4.436,P<0.001)could predict visual span,and increase of 0.146 in the new model(R^(2)=0.209)compared with the original model,showing the interaction item could explain 14.6%of the change of visual span.Conclusion The interactions between CRP and EGF may be related to the cognitive function in patients with schizophrenia,which is helpful to explore objective markers of cognitive deficits in schizophrenia.

关 键 词：精神分裂症 表皮生长因子 C反应蛋白 认知功能 交互作用 神经营养因子 炎症因子 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R363.1[医药卫生—临床医学]