银杏叶提取物对PM2.5致大鼠急性肺损伤的作用研究  

Effects of Ginkgo Biloba Extract on PM2.5-induced Acute Lung Injury in Rats

作　　者：吴喆[1] 孙燕玲 林丽[1] WU Zhe;SUN Yan-ling;LIN Li(School of Basic Medical Sciences,Xianning Medical College,Hubei University of Science and Technology,Xianning Hubei 437100,China)

机构地区：[1]湖北科技学院医学部基础医学院,湖北咸宁437100

出　　处：《湖北科技学院学报（医学版）》2022年第3期212-215,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北省教育厅科学技术研究计划指导性项目(B2020161);湖北科技学院药学重点学科专项科研项目(2019-20YZ03)。

摘　　要：目的探讨银杏叶提取物Egb761对PM2.5致大鼠急性肺损伤的作用。方法采用气管滴注PM2.5建立急性肺损伤模型,通过动物生长状况、W/D、肺系数、肺组织病理学变化和肺功能指标观察Egb761对PM2.5暴露所致急性肺损伤的影响。结果Egb761可拮抗PM2.5造成的生长抑制,减轻肺水肿和肺组织的炎症反应,改善肺脏通气功能,提高肺顺应性。结论银杏叶提取物Egb761能有效缓解PM2.5暴露所致的急性肺损伤。Objective To investigate the effect of Ginkgo biloba extract Egb761 on PM2.5-induced acute lung injury in rats.Methods Cute lung injury model was established by intratracheal instillation of PM2.5.The effects of Ginkgo biloba extract Egb761 on PM2.5 exposure-induced acute lung injury were observed by animal growth status,W/D,pulmonary index,lung histopathological changes and pulmonary function indexes.Results Egb761 could antagonize the growth inhibition caused by PM2.5,alleviate pulmonary edema and inflammatory response of lung tissue,improve pulmonary ventilation function and lung compliance.Conclusion Ginkgo biloba extract Egb761 can effectively relieve acute lung injury caused by PM2.5 exposure.

关 键 词：银杏叶提取物 大气细颗粒物 急性肺损伤 肺功能 

分 类 号：R-332[医药卫生]