益气祛浊方治疗丘脑病变感觉障碍疗效及其对脑血流变化的影响  

Effect of Yiqi Quzhuo Decoction on Sensory Disorders Caused by Thalamic Lesions and Cerebral Blood Flow

作　　者：杨静棉[1] 朱小静[2] 杨雪[2] 岳燕霞 朱志红 YANG Jing-mian;ZHU Xiao-jing;YANG Xue;YUE Yan-xia;ZHU Zhi-hong(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei 050051;The Seventh People′s Hospital of Hebei,Dingzhou Hebei 073000;Dingzhou Traditional Chinese Medicine Hospital,Dingzhou Hebei 073000)

机构地区：[1]石家庄市中医院,河北石家庄050051 [2]河北省第七人民医院,河北定州073000 [3]定州市中医医院,河北定州073000

出　　处：《世界中西医结合杂志》2022年第5期964-968,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研项目(2020605)。

摘　　要：目的探讨益气祛浊方治疗丘脑病变感觉障碍疗效及其对脑血流变化的影响研究。方法选取2017年4月—2019年8月期间石家庄市中医院脑病科收治的92例丘脑病变感觉障碍患者,根据随机数字表法将其分为对照组和治疗组,每组各46例。对照组采用常规西医治疗,治疗组采用益气祛浊方联合常规西药治疗。治疗8周后,观察比较两组患者临床疗效,治疗前后感觉障碍评分、脑血流动力学指标[平均血流速度(Mean flow velocity,Vm)、血管阻力指数(Resistance index,RI)、血管搏动指数(Pulsatility index,PI)]及不良反应情况。结果治疗后治疗组总有效率为88.89%(40/45)明显优于对照组72.73%(32/44),差异有统计学意义(P<0.05)。两组患者治疗后感觉障碍积分(FLA)、手足SW单丝检测评分均较治疗前升高,差异有统计学意义(P<0.05);且治疗组FLA、手足SW单丝检测评分均较对照组明显升高,差异有统计学意义(P<0.05)。两组患者治疗后Vm水平均高于治疗前,PI、RI水平均低于治疗前,差异有统计学意义(P<0.05);且治疗组Vm水平高于对照组,PI、RI水平低于对照组,差异有统计学意义(P<0.05)。治疗期间,治疗组不良反应发生率为22.73%,对照组不良反应发生率为20.00%,两组比较,差异无统计学意义(P<0.05)。结论益气祛浊方联合西药能够有效的改善与治疗丘脑病变导致的感觉障碍,其机制可能与其具有益气、活血、祛痰、化湿、通络之功效,以及能够改善丘脑病变的血液动力学有关。Objective To study the effect of Yiqi Quzhuo Decoction on the sensory disorders caused by thalamic lesions and the cerebral blood flow.Methods A total of 92 patients with sensory disorders caused by thalamic lesions treated in the Shijiazhuang Hospital of Traditional Chinese Medicine from April 2017 to August 2019 were enrolled in this study.They were assigned into a control group and an observation group according to the random number table method,with 46 patients in each group.The control group received conventional western medicine treatment,and the observation group was treated with Yiqi Quzhuo Decoction combined with conventional western medicine.Both groups were treated for eight weeks,and then the clinical efficacy was compared between the two groups.The sensory function scores and cerebral hemodynamic indicators[mean flow velocity(Vm),resistance index(RI),and pulsatility index(PI)]were compared between before treatment and after treatment as well as between the two groups.The adverse reactions of the two groups were recorded during treatment.Results The observation group had higher total effective rate[88.89%(40/45)vs.72.73%(32/44),P<0.05]than the control group.After eight weeks of treatment,the Fugl-Meyer and Lindmark Assessment(FLA)score and Semmes-Weinstein Monofilament Examination(SWME)score in both groups increased compared with those before treatment and were higher in the observation group than in the control group(P<0.05).The treatments in both groups increased the Vm and decreased the PI and RI(P<0.05).Moreover,the observation group had higher Vm and lower PI and RI than the control group(P<0.05).The incidence of adverse reactions in the observation group and the control group was 22.73%and 20%,respectively,which showed no significant difference between the two groups(P>0.05).Conclusion Yiqi Quzhuo Decoction combined with western medicine can treat sensory disorders caused by thalamic lesions.The decoction has the activities of replenishing qi,activating blood,dispelling phlegm,drying dampness,an

关 键 词：丘脑病变 感觉障碍 益气祛浊方 中西医结合 血流动力学 

分 类 号：R741.041[医药卫生—神经病学与精神病学]