Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV  

作　　者：Jingjing Hu Ling Gu Yueming Shao Renfang Zhang Tangkai Qi Jianjun Sun Zhenyan Wang Wei Song Yang Tang Jiangrong Wang Shuibao Xu Junyang Yang Yinzhong Shen Li Liu Jun Chen Hongzhou Lu 

机构地区：[1]School of Public Health,Bengbu Medical College,Bengbu,233000,Anhui,China [2]Department of Infectious Diseases and Immunology,Shanghai Public Health Clinical Center,Fudan University,2901 Caolang Road,Jinshan District,Shanghai,201508,China [3]Shenzhen Third People’s Hospital,The Second Affiliated Hospital of Southern University of Science and Technology,Shenzhen,518000,China

出　　处：《Infectious Diseases of Poverty》2022年第1期47-55,共9页贫困所致传染病（英文）

基　　金：Shanghai Commission of Science and Technology(20MC1920100 and 21Y11901200);Shanghai key Infectious Disease Project(shslczdzk01102);Shanghai Municipal Health Commission(GWV-10.1-XK02);development fund for Shanghai talents(2020089);Shanghai "Rising stars of Medical Talent" Youth Development Program(No. 2019-72)。

摘　　要：Background:Few data are available regarding the long-term case-fatality rate(CFR)among people living with HIV(PLWH)with nontuberculous mycobacteria(NTM)disease.The aim of this study is to analyze the long-term CFR in patients with NTM disease and to identify risk factors for their death.Methods:A retrospective cohort study of 379 cases of microbiologically confirmed NTM disease in PLWH was conducted from January 1,2012,to December 31,2020,in Shanghai,China.We used Kaplan-Meier survival analysis and the log-rank test to compare the long-term CFR in patients with disseminated NTM(DNTM)and localized NTM disease.Univariate Cox proportional hazards regression analysis and a stepwise Cox proportional hazards regression model were used to estimate the predictors of long-term CFR.Results:The cohort was followed up for a median of 26 months.The total CFR was 15.7%by one year and increased to 22.6%at 5 years after the diagnosis of NTM disease.The 5-year CFR of PLWH with DNTM was significantly higher than that of PLWH with localized NTM(26.7%vs 19.6%for DNTM and localized NTM disease,respectively).Older age[hazard ratio(HR)=1.04,95%confidence interval(CI):1.02-1.06,P<0.001],comorbidity(HR=2.05,95%CI:1.21-3.49,P<0.01),DNTM(HR=2.08,95%CI:1.17-3.68,P<0.05),and HIV viral load(HR=1.32,95%CI:1.12-1.55,P<0.001)were all independent risk factors for long-term CFR.In the subgroup analysis,time to culture positivity was negatively correlated with CFR in patients with DNTM(HR=0.90,95%CI:0.82-0.98,P<0.05).Conclusions:NTM was associated with a high long-term CFR in PLWH.Further approaches to prevent NTM disease in PLWH are urgently needed.

关 键 词：HIV/AIDS Nontuberculous MYCOBACTERIA CASE-FATALITY rate Risk FACTOR 

分 类 号：R512.91[医药卫生—内科学]