清热燥湿止泻汤联合美沙拉嗪肠溶片治疗湿热内蕴型溃疡性结肠炎临床研究  

Clinical Study of Qingre Zaoshi Zhixie Tang Combined with Mesalazine EntericCoated Tablets for Ulcerative Colitis of Internal Accumulation of Damp-heat Type

作　　者：彭永剑 王云滨 郑君渭 PENG Yongjian;WANG Yunbin;ZHENG Junwei

机构地区：[1]温岭市第四人民医院,浙江温岭317511 [2]温岭市第一人民医院内科,浙江温岭317500

出　　处：《新中医》2022年第11期107-110,共4页New Chinese Medicine

摘　　要：目的:观察清热燥湿止泻汤联合美沙拉嗪肠溶片治疗湿热内蕴型溃疡性结肠炎(UC)患者的效果。方法:选取90例活动期UC患者,按随机数字表法分为对照组及治疗组各45例。对照组口服美沙拉嗪肠溶片,治疗组在对照组基础上加用清热燥湿止泻汤,2组均连续治疗8周。比较2组临床疗效,比较2组治疗前后主要症状(泄泻、腹痛、脓血便、急后重感)评分及肠镜下肠黏膜评分的变化,比较2组1年后的复发率。结果:治疗8周后,治疗组临床疗效总有效率为95.56%,对照组为82.22%,2组比较,差异有统计学意义(P<0.05)。治疗8周后,2组泄泻、腹痛、脓血便、里急后重感的主要症状评分均较治疗前下降,治疗组上述4项主要症状评分均低于对照组,差异均有统计学意义(P<0.05)。治疗8周后,2组肠镜下肠黏膜评分均较治疗前下降,治疗组肠镜下肠黏膜评分低于对照组,差异均有统计学意义(P<0.05)。对临床总有效者(治疗组43例、对照组37例)1年后进行随访,治疗组复发率为23.26%,对照组为45.95%,2组比较,差异有统计学意义(P<0.05)。结论:清热燥湿止泻汤联合美沙拉嗪肠溶片治疗湿热内蕴型UC患者的疗效确切,可减轻临床症状,促进肠黏膜愈合,降低复发率。Objective:To observe the effect of the therapy of Qingre Zaoshi Zhixie tang combined with mesalazine enteric-coated tablets on patients with ulcerative colitis(UC)of internal accumulation of damp-heat type.Methods:A total of90 patients with UC in active stage were selected and divided into the control group and the treatment group according to the random number table method,with 45 cases in each group.The control group was treated with oral administration of mesalazine enteric-coated tablets,and the treatment group was additionally treated with Qingre Zaoshi Zhixie tang based on the treatment of the control group.Both groups were treated for eight weeks.The clinical effects in the two groups were compared.Before and after treatment,the changes in the scores of main symptoms,including diarrhea,abdominal pain,stool containing pus and blood and abdominal urgency with rectal heaviness,and the scores of intestinal mucosa under colonoscopy were compared between the two groups.The recurrence rates in the two groups after one year were followed up and observed.Results:After eight weeks of treatment,the total effective rate was 95.56%in the treatment group,and was 82.22%in the control group,the difference being significant(P<0.05).After eight weeks of treatment,the scores of main symptoms,including diarrhea,abdominal pain,stool containing pus and blood and abdominal urgency with rectal heaviness,in the two groups were decreased when compared with those before treatment,and the above four scores in the treatment group were lower than those in the control group,differences being significant(P<0.05).After eight weeks of treatment,the scores of intestinal mucosa under colonoscopy in both groups were decreased when compared with those before treatment,and the scores in the treatment group were lower than those in the control group,differences being significant(P<0.05).The clinical effective patients,with 43 cases in the treatment group and 37 cases in the control group,were followed up for one year,and the recurrence rate was

关 键 词：溃疡性结肠炎 湿热内蕴型 清热燥湿止泻汤 美沙拉嗪肠溶片 复发率 

分 类 号：R574.64[医药卫生—消化系统]