VEGF、LDH及β_(2)-MG在急性白血病患者中的检测价值探究  

Investigation on the detection value of VEGF,LDH andβ_(2)-MG in patients with acute leukemia

作　　者：段相会 李云[1] 李苗 朱映霞[1] 黄丽珍[1] 符美华[1] 李少燕 陈启兰[1] DUAN Xiang-hui;LI Yun;LI Miao(Qinzhou First People's Hospital of Guangxi Zhuang Autonomous Region,Qinzhou 535000,China)

机构地区：[1]广西壮族自治区钦州市第一人民医院,535000

出　　处：《中国现代药物应用》2022年第9期9-12,共4页Chinese Journal of Modern Drug Application

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(项目编号:E20180258);项目名称:血管内皮生长因子及乳酸脱氢酶和β_(2)-微球蛋白在急性白血病诊断及预后中的价值。

摘　　要：目的探究与分析血管内皮生长因子(VEGF)、乳酸脱氢酶(LDH)及β_(2)微球蛋白(β_(2)-MG)在急性白血病患者中的检测价值及与疾病情况的关系。方法选取80例急性白血病患者作为观察组,另选同期80例体检健康者作为对照组。检测两组的血清VEGF、LDH及β_(2)-MG水平。比较两组的血清VEGF、LDH及β_(2)-MG水平;比较观察组中不同疾病分型、不同危险度分层、不同疾病状态患者的VEGF、LDH及β_(2)-MG水平;分析急性白血病患者血清VEGF、LDH及β_(2)-MG与危险度分层的关系。结果观察组的血清VEGF(126.56±13.68)pg/ml、LDH(669.39±75.63)U/L及β_(2)-MG(3.19±0.39)mg/L均显著高于对照组的(56.36±6.37)pg/ml、(163.63±18.97)U/L及(1.86±0.17)mg/L,差异有统计学意义(P<0.05)。观察组中急性淋巴细胞白血病和急性非淋巴细胞白血病患者的血清VEGF、LDH及β_(2)-MG水平比较,差异均无统计学意义(P>0.05)。观察组中不同危险度分层患者的血清VEGF、LDH及β_(2)-MG水平比较,差异有统计学意义(P<0.05);高危患者的血清VEGF、LDH及β_(2)-MG水平显著高于中危和低危患者,中危患者的血清VEGF、LDH及β_(2)-MG水平显著高于低危患者,差异有统计学意义(P<0.05)。观察组中不同疾病状态患者的血清VEGF、LDH及β_(2)-MG水平比较,差异有统计学意义(P<0.05);未缓解及复发患者的血清VEGF、LDH及β_(2)-MG水平均显著高于缓解患者,差异有统计学意义(P<0.05);而未缓解及复发患者的血清VEGF、LDH及β_(2)-MG水平比较,差异无统计学意义(P>0.05)。Pearson相关分析显示,急性白血病患者的血清VEGF、LDH及β_(2)-MG水平与危险度分层呈正相关(r=0.789、0.831、0.861,P<0.05)。结论血清VEGF、LDH及β_(2)-MG在急性白血病患者中的检测价值较高,且与急性白血病危险度分层及疾病状态有一定的关系,可反映患者病情严重程度。Objective To investigate and analyze the detection value of vascular endothelial growth factor(VEGF),lactate dehydrogenase(LDH)andβ_(2)-microglobulin(β_(2)-MG)in patients with acute leukemia and its correlation with disease situation.Methods 80 patients with acute leukemia were selected as the observation group,and 80 healthy individuals who underwent physical examination during the same period were selected as the control group.The serum levels of VEGF,LDH andβ_(2)-MG were detected in the two groups.Comparison was made on serum levels of VEGF,LDH andβ_(2)-MG between the two groups,as well as the serum levels of VEGF,LDH andβ_(2)-MG in patients with different disease types,risk stratification and disease states in the observation group.The correlation of serum VEGF,LDH,β_(2)-MG and risk stratification in acute leukemia patients was analyzed.Results The serum VEGF(126.56±13.68)pg/ml,LDH(669.39±75.63)U/L andβ_(2)-MG(3.19±0.39)mg/L in observation group were significantly higher than(56.36±6.37)pg/ml,(163.63±18.97)U/L and(1.86±0.17)mg/L in control group,and the difference was statistically significant(P<0.05).In the observation group,there was no statistically significant difference in serum levels of VEGF,LDH andβ_(2)-MG between patients with acute lymphocytic leukemia and acute non-lymphocytic leukemia(P>0.05).In the observation group,the serum levels of VEGF,LDH andβ_(2)-MG were compared in the patients with different risk stratification,and the difference was statistically significant(P<0.05).The serum levels of VEGF,LDH andβ_(2)-MG in high-risk patients were significantly higher than those in intermediate-risk and low-risk patients,and the serum levels of VEGF,LDH andβ_(2)-MG in intermediate-risk patients were significantly higher than those in low-risk patients.All the differences were statistically significant(P<0.05).In the observation group,the serum levels of VEGF,LDH andβ_(2)-MG in patients with different disease states were compared,and the differences were statistically significant(P<0.

关 键 词：血管内皮生长因子 乳酸脱氢酶 血清β_(2)微球蛋白 急性白血病 检测价值 

分 类 号：R733.71[医药卫生—肿瘤]