DNA损伤修复和遗传缺陷导致的脂肪分化异常及胰岛素抵抗的研究进展  

Abnormal adipose differentiation and insulin resistance caused by DNA damage repair and genetic defects

作　　者：彭雅洁 朱文娇[1] 施缘萍 乔洁[1] Peng Yajie;Zhu Wenjiao;Shi Yuanping;Qiao Jie(Department of Endocrinology,the 9th People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院内分泌科,200011

出　　处：《国际内分泌代谢杂志》2022年第3期219-222,共4页International Journal of Endocrinology and Metabolism

基　　金：上海市自然科学基金资助项目(21ZR1438300)。

摘　　要：脂肪组织不仅是体内的储能器官,而且是重要的内分泌器官,各种原因引起的脂肪细胞分化异常,会影响机体能量平衡,导致代谢异常。脂肪分化异常与胰岛素抵抗相关,是近年来内分泌代谢领域的研究热点。DNA损伤修复异常会影响脂肪分化过程;同时,DNA损伤修复网络中相关基因突变可引起罕见遗传代谢综合征,表现为脂肪萎缩、胰岛素抵抗及早衰等表型。本文探讨DNA损伤修复与脂肪分化异常的关系,以及这些特殊临床表型潜在的分子机制。Adipose tissue is not only an energy storage organ in the body,but also a crucial endocrine organ.Abnormal differentiation of adipocytes caused by various reasons will affect the energy balance of the body,leading to disordered metabolism.Abnormal adipocyte differentiation is related to insulin resistance which is also a research focus in the field of metabolism recently.DNA damage will affect the process of adipogenic differentiation;meanwhile,the rare genetic metabolic syndrome caused by gene mutations in DNA damage repair network exhibit abnormal adipose differentiation,such as fat atrophy,insulin resistance and premature senility.In this paper,the relationship between DNA damage repair and abnormal adipose differentiation will be discussed,as well as the potential molecular mechanism of these special clinical phenotypes.

关 键 词：DNA损伤 脂肪细胞分化异常 胰岛素抵抗 基因突变 

分 类 号：R589[医药卫生—内分泌]