线粒体丙酮酸转运载体在中枢神经系统退行性疾病中作用的研究进展  

Research progress on the role of mitochondrial pyruvate carrier in central nervous system degenerative diseases

作　　者：仇念壮 王丽宏 张雪辉 王浩 QIU Nianzhuang;WANG Lihong;ZHANG Xuehui;WANG Hao(Institute of Pharmacology,Shandong First Medical University,Tai'an 271016,China;Chaoyang District,968 Hospital of the People's Liberation Army,Chaoyang 122000,China)

机构地区：[1]山东第一医科大学药理学研究所,山东泰安271016 [2]解放军第968医院朝阳院区,辽宁朝阳122000

出　　处：《老年医学研究》2022年第3期47-51,共5页Geriatrics Research

摘　　要：线粒体丙酮酸转运载体(MPC)作为控制丙酮酸由胞质进入线粒体的结构,参与许多疾病的发生,如癌症、代谢性疾病等。近年研究发现,MPC与中枢神经系统退行性疾病密切相关。本文就MPC对阿尔茨海默症认知功能的改善作用、帕金森病的神经保护和抗炎作用、亨廷顿舞蹈病精神障碍的改善作用进行综述,以期为上述疾病的治疗提供新的方向和依据。Mitochondrial pyruvate carrier(MPC)as a structure controlling pyruvate from cytoplasm to mitochondria,is involved in the occurrence of many diseases,such as cancer,metabolic diseases and so on.Recent studies have found that MPC is closely related to central nervous system degenerative diseases.This article reviews the effects of MPC on the improvement of cognitive function in Alzheimer's disease,neuroprotective and anti-inflammatory effects in Parkinson's disease,and the improvement of mental disorders in Huntington's disease,in order to provide a new direction and basis for the treatment of these diseases.

关 键 词：线粒体丙酮酸转运载体 中枢神经系统退行性疾病 阿尔茨海默症 帕金森病 亨廷顿舞蹈病 

分 类 号：R741[医药卫生—神经病学与精神病学]