内脏脂肪在肺癌中的研究进展  

Research progress of visceral fat in lung cancer

作　　者：李岳航 王愿 李义帅 赵敏[2] LI Yuehang;WANG Yuan;LI Yishuai;ZHAO Min(The Affiliated Hospital of Hebei University,Baoding 071000,China;不详)

机构地区：[1]河北大学附属医院,河北保定071000 [2]河北省胸科医院肿瘤二科,石家庄050000 [3]河北省胸科医院胸三科,石家庄050000

出　　处：《实用医学杂志》2022年第10期1292-1297,共6页The Journal of Practical Medicine

基　　金：河北省医学科学研究课题计划(编号:20191008);政府资助卫生健康优秀人才专项经费(编号:361013)。

摘　　要：肺癌的发病率逐渐上升,是癌症死亡居首位的癌种。目前肥胖已被视为影响人类健康的主要问题之一,内脏脂肪能够更加准确的反映患者脂肪的分布情况,有多种测量内脏脂肪的方法,每一种都有其优缺点,寻找最优化的内脏脂肪评估指标非常重要,目前应用最为广泛的是腹部CT检查。越来越多证据表明内脏脂肪与包括肺癌在内的实体肿瘤的发生发展密切相关,高内脏脂肪的人群具有较大的肺癌发生风险,高内脏脂肪可以促进肺癌的发生发展,影响患者预后,伴有高内脏脂肪的肺癌患者具有更好的化疗耐受性,更高的免疫治疗疗效,更多的免疫治疗相关不良反应。机制可能与内脏肥胖引起的炎症、脂肪因子分泌失衡和微环境稳态的破坏有关。深入了解内脏脂肪测量的方法,及其对肺癌发生发展、临床预后评估和临床治疗的影响,将对肺癌的预防提供新的思路,在抗肿瘤治疗过程中,关注患者的营养状况,会对治疗产生积极作用。本文首次对近十年来内脏脂肪与肺癌的研究文献综述如下。Lung cancer is becoming more common,and it is the leading cause of cancer deaths.Obesity has long been regarded as one of the most serious health issues.There are various methods of measuring visceral fat,each of which exists advantages and disadvantages.Visceral fat can provide a more accurate representation of fat distribution in patients.More and more evidence shows that visceral fat is closely related to the occurrence and development of solid tumors including lung cancer.People who have a lot of visceral fat are more likely to get lung cancer.High visceral fat levels can promote the occurrence and progression of lung cancer and have an impact on patients′prognoses.Lung cancer patients with high visceral fat have better chemotherapy tolerance,higher immuno⁃therapy efficacy,and more immunotherapy⁃relatedside effects.Paying attention to patients′nutritional status will benefit their treatment during the anti⁃tumor therapy process.For the first time,the article reviewed the last ten years of literature on the relationship between visceral fat and lung cancer.

关 键 词：肺癌 内脏脂肪 内脏肥胖 相关性 

分 类 号：R734.2[医药卫生—肿瘤]