肌电生物反馈疗法联合奥拉西坦对老年血管性痴呆患者外周血血红素氧化酶-1、可溶性凋亡因子水平及认知功能的影响  

Effects of electromyography biofeedback therapy combined with oxiracetam on peripheral blood heme oxidase-1,soluble apoptotic molecules and cognitive function in patients with senile vascular dementia

作　　者：刘亚林 郭医杰 孟文娟 孔咏梅 Liu Yalin;Guo Yijie;Meng Wenjuan;Kong Yongmei(Department of Neurology,Xingtai Third Hospital,Xingtai 054000,China)

机构地区：[1]邢台市第三医院神经内四科,邢台054000

出　　处：《中国医师进修杂志》2022年第6期559-563,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨肌电生物反馈疗法联合奥拉西坦对老年血管性痴呆(VaD)患者外周血血红素氧化酶-1(HO-1)、可溶性凋亡因子水平及认知功能的影响。方法选取邢台市第三医院2018年5月至2020年5月收治的老年VaD患者114例,按随机数字表法分为对照组和观察组,每组57例。两组均给予常规治疗,对照组在常规治疗基础上给予奥拉西坦,观察组在常规治疗基础上给予肌电生物反馈疗法联合奥拉西坦。治疗1个月后比较两组治疗效果,比较两组治疗前后血清HO-1和可溶性凋亡因子sFas、sFasL水平,认知功能评定采用韦氏记忆量表(WMS)、简易精神状态量表(MMSE),神经功能评定采用中国卒中量表(CSS),生活能力评定采用日常生活能力量表(ADL),并记录两组不良反应发生情况。结果观察组总有效率高于对照组[93.0%(53/57)比77.2%(44/57)],差异有统计学意义(P<0.05)。治疗后两组血清HO-1均高于治疗前,并且观察组高于对照组[(30.21±4.05)μg/L比(24.19±3.47)μg/L],差异均有统计学意义(P<0.05)。治疗后两组血清sFas、sFasL水平较治疗前均降低,并且观察组低于对照组[(81.57±16.23)ng/L比(118.49±25.09)ng/L、(135.47±24.41)ng/L比(200.71±30.29)ng/L],差异均有统计学意义(P<0.05)。治疗后观察组CSS评分低于对照组[(13.48±2.15)分比(17.22±3.02)分],WMS、MMSE、ADL评分高于对照组[(97.75±10.27)分比(88.43±9.16)分、(23.82±2.50)分比(21.38±2.19)分、(60.16±6.24)分比(51.29±5.52)分],差异均有统计学意义(P<0.05)。治疗后两组不良反应发生率比较差异无统计学意义(P>0.05)。结论肌电生物反馈疗法联合奥拉西坦治疗老年VaD患者疗效显著,可明显改善血管内皮功能,调节凋亡因子,强化认知功能,促进神经功能及日常生活能力恢复,且不增加不良反应。Objective To explore the effect of electromyography biofeedback therapy combined with oxiracetam on peripheral blood heme oxidase-1(HO-1),soluble apoptotic molecules and cognitive function in patients with senile vascular dementia(VaD).Methods One hundred and fourteen elderly patients with VaD from May 2018 to May 2020 in Xingtai Third Hospital were selected and divided into two groups according to the random number table method,with 57 cases in each group.Both groups were given conventional treatment.On this basis,the control group was given oxiracetam,and the observation group was given electromyography biofeedback therapy combined with oxiracetam.The treatment effects after treated for 1 month was compared between the two groups.The levels of serum HO-1,soluble apoptotic molecules sFas,sFasL before and after treatment were compared between the two groups.Cognitive function evaluated by Wechsler Memory Scale(WMS),Mini Mental State Examination(MMSE).The scores of Chinese Stroke Scale(CSS),Ability of Daily Living(ADL)before and after treatment and adverse reactions were compared between the two groups.Results After treated for 1 month,the total effective rate in the observation group was higher than that in the control group:93.0%(53/57)vs.77.2%(44/57),the difference was statistically significant(P<0.05).After treated for 1 month,the level of serum HO-1 in the two groups was higher than that before treatment,and the level of serum HO-1 in the observation group was higher than that in the control group:(30.21±4.05)μg/L vs.(24.19±3.47)μg/L,the difference was statistically significant(P<0.05).The levels of serum sFas and sFasL in two groups after treatment were lower than those before treatment,and the levels of serum sFas and sFasL in the observation group were lower than those the control group after treatment:(81.57±16.23)ng/L vs.(118.49±25.09)ng/L,(135.47±24.41)ng/L vs.(200.71±30.29)ng/L,the differences were statistically significant(P<0.05).After treated for 1 month,the CSS scores in the observation gro

关 键 词：痴呆 血管性 血红素氧化酶(脱环) 认知 肌电生物反馈疗法 奥拉西坦 

分 类 号：R749.13[医药卫生—神经病学与精神病学]