闭合性眼外伤氧化三甲胺表达与眼底出血的相关性研究  

Correlation between trimethylamine oxide expression of closed ocular trauma and fundus hemorrhage

作　　者：潘俊辉[1] 高延庆[1] 孙艳华[1] 杨媛媛[1] Pan Junhui;Gao Yanqing;Sun Yanhua;Yang Yuanyuan(Department of Ophthalmology,Zhengzhou Municipal Second People’s Hospital,Zhengzhou 450015,China)

机构地区：[1]郑州市第二人民医院眼科,郑州450015

出　　处：《中华眼外伤职业眼病杂志》2022年第6期425-429,共5页Chinese Journal of Ocular Trauma and Occupational Eye Disease

摘　　要：目的探讨闭合性眼外伤患者玻璃体和视网膜的氧化三甲胺(TMAO)表达与继发性眼底出血的相关性。方法前瞻性随机对照研究。纳入2020年1月至2021年7月郑州市第二人民医院闭合性眼外伤108例(108眼),患者分成两组,其中继发性眼底出血者45例为出血组,无继发性出血者63例为无出血组;同期特发性黄斑孔者50例(50眼)作为对照组。采用稳定同位素稀释液相色谱-串联质谱法检测玻璃体和视网膜的TMAO表达量。结果出血组玻璃体和视网膜的TMAO表达量均高于无出血组(t=8.12,7.19;均P<0.001),无出血组高于对照组(t=8.55,5.64;均P<0.001)。根据眼外伤评分系统(OTS)将患者评分为1~5级。等级越低病情越严重,TMAO表达量也越高。出血组术后视力(BCVA)≥1.0者玻璃体和视网膜TMAO表达量明显低于视力<1.0者(t=3.96,3.30;均P<0.01)。结论闭合性眼外伤患者玻璃体和视网膜的TMAO表达量升高可能与继发眼底出血的风险增加、病情严重程度以及术后视力低下有关。Objective To investigate the correlation between the expression of trimethylamine oxide(TMAO)and fundus hemorrhage in patients with closed ocular trauma.Methods This was a prospective randomized control study.A total of 108 eyes of 108 patients with closed ocular trauma from Jan.2020 to Jul.2021 in Zhengzhou Municipal Second People’s Hospital were included.All cases were divided into two groups,including 45 patients of secondary fundus hemorrhage as the hemorrhage group and 63 patients of non-secondary hemorrhage as the non-hemorrhage group;at the same time,50 eyes of 50 patients with idiopathic macular hole were selected as the control group.The expression of TMAO in vitreous and retina was detected by stable isotope dilution liquid chromatography tandem mass spectrometry.Results The expression levels of TMAO in the vitreous and retina of the hemorrhage group were higher than those of the non-hemorrhage group(t=8.12,7.192;all P<0.001),and some of the non-hemorrhage group was higher than those of the control group(t=8.55,5.64;all P<0.001).According to the Ocular Trauma Scoring System(OTS),patients were graded from 1 to 5.The lower the grade,the more severe the disease,and the higher the TMAO expression level.The postoperative visual acuity(BCVA)≥1.0 in the hemorrhage group had significantly lower vitreoretinal TMAO expression than in those with visual acuity<1.0(t=3.96,3.30;all P<0.01).Conclusion Higher expression of TMAO in vitreous and retina tissue in patients with closed ocular trauma may be related to the increasing risk of secondary fundus hemorrhage,the severity of disease and worse postoperative visual acuity.

关 键 词：氧化三甲胺 玻璃体 视网膜 外伤 眼 闭合性 出血 眼底 

分 类 号：R779.1[医药卫生—眼科]