经颅直流电刺激下脑卒中患者脑电功率谱密度研究  

Research on electroencephalogram power spectral density of stroke patients under transcranial direct current stimulation

作　　者：刘蒙蒙 徐桂芝[1,2] 于洪丽[1,2] 王春方[3] 孙长城[3] 郭磊[1,2] LIU Mengmeng;XU Guizhi;YU Hongli;WANG Chunfang;SUN Changcheng;GUO Lei(State Key Laboratory of Reliability and Intelligence of Electrical Equipment,School of Electrical Engineering,Hebei University of Technology,Tianjin 300130,P.R.China;Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health,Hebei University of Technology,Tianjin 300130,P.R.China;Rehabilitation Medical Department,Tianjin Union Medical Center,Tianjin 300121,P.R.China)

机构地区：[1]河北工业大学电气工程学院,省部共建电工装备可靠性与智能化国家重点实验室,天津300130 [2]河北工业大学电气工程学院,天津市生物电工与智能健康重点实验室,天津300130 [3]天津市人民医院康复医学科,天津300121

出　　处：《生物医学工程学杂志》2022年第3期498-506,共9页Journal of Biomedical Engineering

基　　金：国家自然科学基金(51877068,81871469,52077056,82102652)。

摘　　要：经颅直流电刺激(tDCS)已成为卒中后康复治疗的新手段,并且逐渐被人们所接受。然而,tDCS治疗脑卒中的神经生理机制仍需进一步探讨。本文纳入了30例大脑左侧受损的脑卒中患者,随机分为tDCS真刺激组(15例)和tDCS伪刺激组(15例)。采集两组受试者刺激前、后的静息态脑电(EEG)信号,分析对比刺激前、后EEG信号δ、θ、α和β频带的功率谱密度差异,并计算了δ/α功率比值(DAR)。结果发现,真刺激后δ频带能量在左颞叶区明显降低,差异具有统计学意义(P <0.05);α频带能量在枕叶区明显增强,差异具有统计学意义(P <0.05);θ和β频带能量在整个脑区的差异不具有统计学意义(P> 0.05)。伪刺激前、后δ、θ、α和β频带能量在整个脑区的差异不具有统计学意义(P> 0.05)。另一方面,真刺激后脑卒中患者的DAR值明显降低,差异具有统计学意义(P <0.05),伪刺激后DAR值差异不具有统计学意义(P> 0.05)。本研究在一定程度上揭示了tDCS治疗脑卒中的神经生理机制。Transcranial direct current stimulation(tDCS) has become a new method of post-stroke rehabilitation treatment and is gradually accepted by people. However, the neurophysiological mechanism of tDCS in the treatment of stroke still needs further study. In this study, we recruited 30 stroke patients with damage to the left side of the brain and randomly divided them into a real tDCS group(15 cases) and a sham tDCS group(15 cases). The resting EEG signals of the two groups of subjects before and after stimulation were collected, then the difference of power spectral density was analyzed and compared in the band of delta, theta, alpha and beta, and the delta/alpha power ratio(DAR) was calculated.The results showed that after real tDCS, delta band energy decreased significantly in the left temporal lobes, and the difference was statistically significant(P < 0.05);alpha band energy enhanced significantly in the occipital lobes, and the difference was statistically significant(P < 0.05);the difference of theta and beta band energy was not statistically significant in the whole brain region(P > 0.05). Furthermore, the difference of delta, theta, alpha and beta band energy was not statistically significant after sham tDCS(P > 0.05). On the other hand, the DAR value of stroke patients decreased significantly after real tDCS, and the difference was statistically significant(P < 0.05), and there was no significant difference in sham tDCS(P > 0.05). This study reveals to a certain extent the neurophysiological mechanism of tDCS in the treatment of stroke.

关 键 词：经颅直流电刺激 脑卒中 脑电图 功率谱密度 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R493[医药卫生—临床医学]