肝脏调节胆固醇代谢稳态的研究进展  

Progress in liver regulation of cholesterol homeostasis

作　　者：林洁 陈玉霞 章卫平 LIN Jie;CHEN Yuxia;ZHANG Weiping(Department of Pathophysiology,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学病理生理学教研室,上海市200433

出　　处：《中国动脉硬化杂志》2022年第9期737-743,共7页Chinese Journal of Arteriosclerosis

基　　金：国家重点研发计划(2019YFA0802500);国家自然科学基金重大研究计划(91857203、31730042)资助。

摘　　要：胆固醇代谢稳态是机体发挥生理功能的重要保障。胆固醇代谢紊乱引起的体内胆固醇异常积聚可导致肝脏脂肪病变以及高胆固醇血症,与动脉粥样硬化等心血管疾病的发生发展密切相关。肝脏在维持机体胆固醇代谢稳态过程中发挥着关键性作用,其胆固醇代谢涉及摄取、合成、生物转化以及外排等多个环节。文章就肝脏调节胆固醇代谢稳态的最新进展作一综述。Cholesterol homeostasis is critical for proper cellular function in the organism.Abnormal accumulation of cholesterol in the body caused by metabolic disorder can lead to hepatic steatosis and hypercholesterolemia,which is closely correlated to cardiac cerebrovascular disease such as arteriosclerosis.The liver plays a key role in maintaining cholesterol homeostasis through regulating its uptake,biosynthesis,conversion,and efflux.This paper reviews the progress in the regulation of cholesterol metabolic homeostasis by the liver.

关 键 词：动脉粥样硬化 高胆固醇血症 脂质代谢 脂质稳态 分泌与外排 

分 类 号：R363[医药卫生—病理学] R589[医药卫生—基础医学]