Non-alcoholic fatty liver disease development:A multifactorial pathogenic phenomena  

作　　者：Aamir Bashir Ajay Duseja Arka De Manu Mehta Pramil Tiwari 

机构地区：[1]Department of Pharmacy Practice,National Institute of Pharmaceutical Education and Research,S.A.S.Nagar,Mohali,Punjab,India [2]Department of Hepatology,Post Graduate Institute of Medical Education and Research,Chandigarh,India

出　　处：《Liver Research》2022年第2期72-83,共12页肝脏研究（英文）

摘　　要：Non-alcoholic fatty liver disease(NAFLD),characterized by the accumulation of excessive intrahepatic fat,is a leading metabolic disorder also considered as the hepatic manifestation of metabolic syndrome(MS).Though more commonly observed in obese individuals and those with metabolic risk factors,it also develops in a considerable number of non-obese individuals as well as participants without having any component of MS.The basic mechanism involved in the development of fatty liver is the imbalance between lipid uptake,synthesis,and metabolism in the liver,normally controlled by several mechanisms to maintain lipid homeostasis.As a complex progressive liver disorder,the NAFLD pathogenesis is multifactorial,and several new pathogenic phenomena were discovered over time.The available literature suggests the role of both genetic and environmental factors and associated metabolic factors;however,the mechanism of progression is not completely understood.In this review,we discuss different pathogenic mechanisms and their interplay to provide an elaborate idea regarding NAFLD development and progression.Better understanding of pathogenic mechanisms will be useful in finding new treatment for patients with NAFLD.

关 键 词：Metabolic syndrome(MS) Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) Fatty liver STEATOHEPATITIS Insulin resistance(IR) Lysosomal acid lipase(LAL) 

分 类 号：R575.5[医药卫生—消化系统]