NRP1和TGF-β1 在涎腺腺样囊性癌组织中的表达与意义  

NRP1/TGF-β1 expression and its significance in salivary adenoid cystic carcinoma

作　　者：杨永超 安峰[1] 王钟华[1] YANG Yongchao;AN Feng;WANG Zhonghua(Department of Stomatology,The First Affiliated Hospital of Hebei North College,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院口腔科,河北张家口075000

出　　处：《皖南医学院学报》2022年第3期264-266,270,共4页Journal of Wannan Medical College

基　　金：张家口市市级科技计划自筹经费项目(2021054D)。

摘　　要：目的:检测NRP1、TGF-β1在涎腺腺样囊性癌(SACC)组织的表达水平,分析NRP1、TGF-β1与SACC的癌症机制可能存在的相关性。方法:以免疫组化SABC法分别检测NRP1和TGF-β1在51例SACC组织、20例涎腺正常组织中的表达水平。结果:在SACC组织中,NRP1和TGF-β1的阳性细胞表达率(62.7%和58.8%)均高于涎腺正常组织(35.0%和30.0%)(P<0.05)。NRP1和TGF-β1在SACC组织中的表达水平与肿瘤的组织学类型、临床分期、肿瘤细胞是否侵犯到颈部淋巴结以及是否侵犯到周围神经有关(P<0.05),而与患者的性别、患病年龄相关性无统计学意义(P>0.05)。NRP1和TGF-β1在SACC组织中的表达呈正相关(r_(s)=0.344,P=0.014)。结论:NRP1、TGF-β1与SACC的病情发展相关。Objective:To detect neuropilin 1(NRP1)and transforming growth factorβ1(TGF-β1)expression in the tissues of salivary adenoid cystic carcinoma(SACC),and analyze the potential mechanism of NRP1 and TGF-β1 in SACC.Methods:Immunohistochemistry was used to measure the expression of NRP1 and TGF-β1 in the tissues of SACC cases and in normal salivary tissues from 20 volunteers.Results:The positive rates of NRP1 and TGF-β1 were significantly higher in SACC tissues(62.7%and 58.8%)than in normal salivary tissues(35.0%and 30.0%)(P<0.05).NRP1 and TGF-β1 expression in SACC was closely related with the histological grade,clinical stage,presence or absence of metastasis to cervical lymph node and invasion into the peripheral nerves(P<0.05),yet not associated with patient′s gender or age at diagnosis(P>0.05).NRP1 and TGF-β1 were in positive correlation with SACC(r_(s)=0.344,P=0.014).Conclusion:Present findings suggest that NRP1 and TGF-β1 are involved in the progression of SACC.

关 键 词：涎腺腺样囊性癌 NRP1 TGF-Β1 免疫组化 

分 类 号：R739.87[医药卫生—肿瘤] R392.1[医药卫生—临床医学]