Anti-diabetic and anti-hyperlipidemic effects of sea cucumber(Cucumaria frondosa) gonad hydrolysates in type Ⅱ diabetic rats  

作　　者：Tingting Wang Lin Zheng Shuguang Wang Mouming Zhao Xiaoling Liu 

机构地区：[1]College of Light Industry and Food Engineering,Guangxi University,Nanning 530004,China [2]Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center,Guangzhou 510650,China [3]School of Food Science and Engineering,South China University of Technology,Guangzhou 510640,China

出　　处：《Food Science and Human Wellness》2022年第6期1614-1622,共9页食品科学与人类健康（英文）

基　　金：supported by the Natural Science Foundation of Guangxi(2016GXNSFEA380003);Guangxi Science and Technology Major Special Project(AA17204075);Guangxi Science and Technology Major Special Project(AA4102);Shandong Provincial Key R&D Program(LJNY202018)。

摘　　要：The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates(SCGH)in a rat model of type II diabetes induced by streptozotocin(STZ)combined with high-fat diet(HFD).Results showed that SCGH significantly reduced water intake,fasting blood glucose level and glycated hemoglobin level.Moreover,the oral glucose tolerance,insulin resistance and plasma lipid level in diabetic rats were also alleviated.Furthermore,histological analysis showed that SCGH effectively protected the tissue structure of liver.In addition,mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway,and promoted lipid metabolism via activating the AMPK signaling pathway.In summary,these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders.

关 键 词：Sea cucumber gonad Bioactive peptide Anti-diabetic activity Insulin resistance 

分 类 号：TS254.1[轻工技术与工程—水产品加工及贮藏工程]