首发未治疗精神分裂症缺陷和非缺陷亚型脑结构磁共振研究  

An MRI study of brain structure of deficit and non-deficit types of first-episode drug-naïve patients with schizophrenia.

作　　者：李青[1] 冉娅 魏巍[1] 程勃超 李坤 陈婷[1] 吕笑丽 邓伟[1,4] LI Qing;RAN Ya;WEI Wei;CHENG Bochao;LI Kun;CHEN Ting;LYU Xiaoli;DENG Wei(Mental health center of West China Hospital,Sichuan University,Sichuan 610000,China.)

机构地区：[1]四川大学华西医院心理卫生中心,成都610000 [2]四川大学华西第二医院放射科 [3]苏州广济医院 [4]杭州市第七人民医院

出　　处：《中国神经精神疾病杂志》2022年第3期139-143,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：杭州市生物医药和健康产业发展扶持科技专项研发项目(编号:2021WJCY194);杭州市生物医药和健康产业发展扶持科技专项研发项目(编号:2021WJCY067);苏州市临床医学专家团队引进项目(编号:SZYJTD201715);四川省科技厅重点研发项目(编号:2022YFS0178)。

摘　　要：目的探讨首发未治疗精神分裂症缺陷型与非缺陷型之间大脑的结构差异。方法纳入精神分裂症患者和正常对照,使用缺陷型精神分裂症诊断量表对患者进行分型,采用阳性和阴性症状量表评定患者的症状,所有受试者进行脑结构MRI扫描,采集高分辨T_(1)加权图像后使用基于体素的形态学分析,比较各组脑结构的差异。结果本研究纳入首发未治疗缺陷型与非缺陷型精神分裂症患者各44例,以及正常对照44名。精神分裂症缺陷型患者与正常对照相比白质体积缺损,分布于小脑和左侧丘脑(P<0.05,FWE校正);非缺陷型患者白质及灰质体积与缺陷型患者及正常对照相比均无统计学差异(P>0.05)。非缺陷型患者右侧舌回(r=0.37,P=0.02)及左侧舌回(r=0.39,P=0.01)白质体积与阴性症状存在相关。结论缺陷型精神分裂症在疾病早期白质损伤脑区涉及小脑、丘脑,这为寻找临床特异性指标提供了线索。Objective episode drug-na?ve patients with schizophrenia.MethodsA total of 44 healthy controls,44 deficit schizophrenia patients and 44 non-deficit schizophrenia patients were included.All subjects underwent MRI scanning of brain structure.High resolution T_(1)-weighted images were collected.Voxel-based morphometric analysis was used to compare the differences of brain structure among different subtypes of schizophrenia.ResultsCompared with healthy controls,white matter volume defects were found in the cerebellum and left thalamus in patients with schizophrenia deficits(P<0.05,FWE corrected).There were no significant differences in white matter and gray matter volume among non-deficit and deficit Schizophrenia,healthy controls respectively(P>0.05).White matter volume of right lingual gyrus(r=0.37,P=0.02)and left lingual gyrus(r=0.39,P=0.01)were correlated with negative symptoms in non-deficit patients.Conclusion damage of deficit subtype in cerebellum and thalamus in the early stage of the disease,which may provide clues to identification of disease-specific biomarkers.

关 键 词：精神分裂症 缺陷型精神分裂症 结构磁共振成像 基于体素的形态学分析 白质体积 灰质体积 阴性症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]