Polyphenol-rich Fraction of Terminalia catappa Prevents Chronic LeadAcetate Induced Oxidative Stress and Cardiorenal Toxicities in Rats  

作　　者：Temitayo Ajibade Adedeji Adebayo Ademola Oyagbemi Temidayo Omobowale 

机构地区：[1]Department of Veterinary Physiology and Biochemistry,Faculty of Veterinary Medicine,University of Ibadan,Ibadan 200284,Oyo State,Nigeria [2]Department of Veterinary Medicine,University of Ibadan,Ibadan 200284,Oyo State,Nigeria

出　　处：《Clinical Complementary Medicine and Pharmacology》2022年第2期30-38,共9页临床补充医学和药理学（英文）

摘　　要：Background:Lead(Pb),a naturally occurring environmental contaminant,has been implicated in several pathological conditions of the cardiovascular and renal systems.Objective:The study was designed to evaluate the modulatory roles of the polyphenol-rich fraction of Terminalia catappa on chronic lead acetate-induced cardiovascular and renal toxicities in rats.Methods:Thirty-six rats were randomly selected and divided into six groups of six rats each.Pb toxicity was induced by the administration of 100 mg/L Pb in drinking water for 12 weeks in groups B-F.Groups A and B were left untreated;groups C and D were treated with polyphenol-rich fraction of Terminalia catappa[PRFTC(100 and 200 mg/kg b.w.)];vitamin E(50 mg/kg b.w.)and lisinopril(10 mg/kg b.w.)were administered to groups E and F,respectively.Results:Exposure of rats to Pb induced significantly elevated(P<0.05)primary haemodynamic parameters,severe disseminated congestion of blood vessels and haemorrhages in the cardiac and renal tissues,significantly elevated(P<0.05)markers of oxidative stress markers of inflammation and myocardial infarction,but significantly decreased serum nitric oxide and the systemic antioxidants.Furthermore,rats exposed to Pb showed heightened immune-positive reactions to Caspase-3,a marker of apoptosis,in both renal and cardiac tissues.All manifestations of Pb-associated toxicities in the cardiovascular and renal systems were alleviated by the PRFTC treatment in rats.Conclusion:The polyphenol-rich fraction of T.catappa proved effective in the reduction of oxidative stressmediated derangements of the physiological homeostasis and decreased apoptosis in the cardiovascular and renal systems of rats chronically exposed to lead acetate toxicities and may therefore have therapeutic potential as a supplement that can be applied in chronic lead poisoning。

关 键 词：Terminalia catappa PHYTOTHERAPY Lead acetate Antioxidant Cardio-renal Rat 

分 类 号：R57[医药卫生—消化系统]