Azetidine synthesis enabled by photo-induced copper catalysis via [3+1] radical cascade cyclization  

作　　者：Jianye Li Lu Yu Yun Peng Bin Chen Rui Guo Xiaodong Ma Xiao-Song Xue Yunkui Liu Guozhu Zhang 

机构地区：[1]CCNU-uOttawa Joint Research Centre,Key Laboratory of Pesticides&Chemical Biology Ministry of Education,International Joint Research Center for Intelligent Biosensing Technology and Health,College of Chemistry,Central China Normal University(CCNU),152 Luoyu Road,Wuhan,Hubei 430079,China [2]State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China [3]State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology,College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China [4]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Center for Excellence in Molecular Synthesis,University of Chinese Academy of Sciences,Chinese Academy of Sciences,345 Lingling Road,Shanghai 200032,China

出　　处：《The Innovation》2022年第3期106-114,共9页创新（英文）

基　　金：We are grateful to NSFC-22071073,21772218,21821002,XDB20000000,21933004,the State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences.

摘　　要：Azetidines are an important type of saturated,highly strained,fourmembered,nitrogen-containing heterocyclic compound.These compounds serve as important raw materials,intermediates,and catalysts in organic synthesis,as well as important active units in amino acids,alkaloids,and pharmaceutically active compounds.Thus,the development of an efficient and concise method to construct azetidines is of great significance in multiple disciplines.In this work,we reported on the photo-induced copper-catalyzed radical annulation of aliphatic amines with alkynes to produce azetidines.

关 键 词：SYNTHESIS COPPER RADICAL 

分 类 号：O62[理学—有机化学]