恒古骨伤愈合剂联合特定电磁波治疗气滞血瘀型膝骨关节炎的多维度疗效分析  

Multi-dimensional Efficacy Analysis of TDP Combined with Osteoking in Treatment of Knee Osteoarthritis of Qi Stagnation and Blood Stasis Type

作　　者：谢斌[1] 何海军[1] 闫波 秦卫兵 孙平平[1] 马文虎 谢冲 霍新成 XIE Bin;HE Haijun;YAN Bo;QIN Weibing;SUN Pingping;MA Wenhu;XIE Chong;HUO Xincheng(Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China;The Third People's Hospital of Xinjiang Uygur Autonomous Region,Urumchi 830000,China)

机构地区：[1]中国中医科学院望京医院,北京100102 [2]新疆维吾尔自治区第三人民医院,乌鲁木齐830000

出　　处：《中国实验方剂学杂志》2022年第13期130-136,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：新疆维吾尔自治区卫生与健康适宜技术推广项目(SYTG-202216);国家自然科学基金项目(81873322);新疆维吾尔自治区第三人民医院科研基金项目(2019ZYBYK06)。

摘　　要：目的:多维度评估恒古骨伤愈合剂联合特定电磁波(TDP)治疗气滞血瘀型膝骨关节炎的临床疗效。方法:选取2019年7月至2021年12月于新疆维吾尔自治区第三人民医院诊治的接受保守治疗的104例气滞血瘀型膝骨关节炎患者,按照随机数表法随机分为对照组和观察组,各52例。对照组患者给予TDP治疗,观察组在对照组的基础上给予恒古骨伤愈合剂,两组患者均治疗1周,随访1月,多维度评估两组患者临床疗效。分别于治疗前和治疗后,从主观指标视觉模拟量表(VAS)评分、西安大略和麦克马斯特大学骨关节炎调查量表(WOMAC)评分,客观指标可视化压痛指数、可视化膝关节活动度分别对患者的疼痛和功能进行评估,并测定中医证候积分、测定血清红细胞沉降率(ESR)及高敏C反应蛋白(hs-CRP),综合评定临床总有效率。结果:两组患者基线特征及治疗前各项评分差异均无统计学意义。与本组治疗前比较,两组患者治疗后VAS评分、WOMAC评分、压痛指数、关节活动度、中医证候积分均有显著改善(P<0.01)。与对照组治疗后比较,观察组VAS评分、WOMAC评分显著降低(P<0.01);观察组压痛指数改善程度优于对照组,差异有统计学意义(P<0.05),观察组关节活动度优于对照组,但差异无统计学意义;观察组中医证候积分显著降低(P<0.01)。治疗后两组患者ESR及hs-CRP水平均显著降低,且观察组低于对照组(P<0.01)。临床疗效方面,观察组总有效率为90.4%(47/52),明显高于对照组的53.8%(28/52),差异有统计学意义(P<0.05)。两组治疗期间均未见明显不良反应。结论:恒古骨伤愈合剂联合TDP治疗气滞血瘀型膝骨关节炎的临床疗效显著,从主客观两方面均可改善膝关节疼痛和功能,并可改善中医证候量化指标,降低炎症反应,安全性高。Objective:To evaluate the clinical efficacy of TDP(specific electromagnetic wave)combined with Osteoking in the treatment of knee osteoarthritis of Qi stagnation and blood stasis type.Method:A total of 104 patients with knee osteoarthritis of Qi stagnation and blood stasis type,who received conservative therapy in The Third People's Hospital of Xinjiang Uygur Autonomous Region from July 2019 to December 2021,were randomized into the control group and study group with the random number table method,52 cases in either group.The control group was treated with TDP,and the study group with TDP and Osteoking.The treatment lasted 1 week for both groups,with 1-month follow-up.Subjective indexes of visual analog scale(VAS)score and Western Ontario McMaster Universities Osteoarthritis Index(WOMAC)score,and objective indexes of visual tenderness index and visual knee range of motion were determined before and after treatment to evaluate the pain and functions of patients.Traditional Chinese medicine(TCM)syndrome score was calculated.The serum erythrocyte sedimentation rate(ESR)and high sensitivity C-reactive protein(hs-CRP)were detected before and after treatment,and the total clinical effective rate was calculated.Result:Before treatment,the baseline information and all the scores of the two groups were comparable.After treatment,the VAS score,WOMAC score,tenderness index,knee range of motion,and TCM syndrome score were improved in both groups(P<0.01).After the treatment,the VAS score and WOMAC score of the study group were lower than those of the control group(P<0.01)and the improvement of tenderness index in the study group was better than that in the control group(P<0.05).The knee range of motion in the study group was better than that in the control group(P=0.061).The TCM syndrome score of study group was lower than that of control group(P<0.01)after treatment.The post-treatment serum ESR and hs-CRP level in the two groups decreased significantly after treatment,and the study group were lower than those of the control

关 键 词：特定电磁波谱 恒古骨伤愈合剂 气滞血瘀型 膝骨关节炎 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学] R2-031R969.4R684.3