牙髓组织工程支架材料研究进展  

Research progress indental pulp tissue engineering scaffolds

作　　者：张林朴[1] 邹慧儒[1] Zhang Linpu;Zou Huiru(Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Central Laboratory of Tianjin Stomatological Hospital,The Affiliated Stomatological Hospital of Nankai University,Tianjin 300041,China)

机构地区：[1]天津市口腔功能重建重点实验室,天津市口腔医院暨南开大学附属口腔医院中心实验室,300041

出　　处：《国际生物医学工程杂志》2021年第6期479-485,共7页International Journal of Biomedical Engineering

基　　金：天津市自然科学基金(18JCYBJC27000);天津市卫健委重点项目(ZD20016);全牙再生与口腔组织功能重建北京市重点实验室开放课题项目(KFKT2017008)。

摘　　要：牙髓坏死可导致牙齿脆性增加,易折裂,并阻碍年轻恒牙牙根持续发育。因此牙髓再生治疗具有重要的临床意义。由于牙髓组织具有复杂、多变的解剖结构且包含神经、血管等多种组织成分,牙髓再生面临诸多挑战。回顾近年来应用组织工程方法探索牙髓组织构建与移植的基础研究和临床应用研究文献,重点讨论适宜支架材料的选择与牙髓组织构建方法。文中述及用于构建牙髓组织的支架材料包括海藻酸钠、壳聚糖、透明质酸,胶原蛋白、明胶、纤维蛋白、丝素蛋白、多肽和自组装多肽、聚乳酸、聚乙醇酸及其共聚物等,简要介绍了其功能特点以及添加生物基质提取物、生长因子等组成的功能修饰或不同功能互补性材料组成的功能改进。结合临床可操作性要求,进一步讨论了由亲水性复合材料或经亲水基团修饰材料制备可注射水凝胶支架材料的组成设计和功能特点,以期为今后牙髓再生研究探索提供一定的借鉴。Pulp necrosis can cause increased tooth fragility and easy fracture,and hinder the sustainable development of young permanent teeth.Therefore,pulp regeneration therapy has important clinical significance.However,due to the complicated and varied anatomical structure of the pulp tissue,and various components such as nerves and blood vessels,there are many challenges in dental pulp regeneration strategy.In this paper,the recent research progress in the application of dental pulp tissue construction and transplantation by tissue engineering method was reviewed,and the selection of suitable scaffold materials and the construction of dental pulp tissue were discussed.The functional characteristics of scaffold materials were described,such as sodium alginate,chitosan,hyaluronic acid,collagen,gelatin,fibrous protein,silk fibroin,peptides and self-assembled peptides,polylactic acid,polyglycolic acid and their copolymers.In addition,the functions and characteristics of these materials were briefly introduced,as well as the functional modification with growth factors and other biological matrix extract involvement,and functional improvement of the composite scaffolds with complementary effects.Combined with the requirements of clinical operability,the composition design and functional characteristics of the injectable hydrogel scaffolds consisted of hydrophilic composite materials and/or modified with hydrophilic groups were also discussed.This review paper would be useful in providing some reference for the future research and exploration of dental pulp regeneration.

关 键 词：牙髓再生 牙髓-牙本质复合体 复合支架材料 水凝胶 

分 类 号：R783.1[医药卫生—口腔医学]