血清I-FABP、SM22水平对急性肠系膜缺血患者发生肠坏死的预测价值  

Predictive value of serum I-FABP and SM22 levels on intestinal necrosis in patients with acute mesenteric ischemia

作　　者：张伟伟[1] 王家旭 黄炎东 刘鑫[2] 罗显克[3] ZHANG Weiwei;WANG Jiaxu;HUANG Yandong;LIU Xin;LUO Xianke(Department of Gastroenterology,Nanning First People's Hospital,Nanning 530022,China;不详)

机构地区：[1]南宁市第一人民医院消化内科,南宁530022 [2]广西壮族自治区人民医院消化内科 [3]广西壮族自治区民族医院消化内科

出　　处：《山东医药》2022年第19期20-23,共4页Shandong Medical Journal

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z2015277)

摘　　要：目的探讨血清肠道脂肪酸结合蛋白(I-FABP)、平滑肌22(SM22)水平对急性肠系膜缺血(AMI)患者发生肠坏死的预测价值。方法选取167例AMI患者,根据是否发生肠坏死分为肠坏死组(58例)、无肠坏死组(109例)。收集AMI患者临床资料,用ELISA法检测血清I-FABP、SM22。用多因素Logistics回归分析AMI发生肠坏死的影响因素,受试者工作特征(ROC)曲线分析血清I-FABP、SM22水平对AMI发生肠坏死的预测价值。结果多因素Logistic回归分析显示,乳酸、白细胞计数、I-FABP、SM22是AMI发生肠坏死的影响因素(P均<0.05)。I-FABP+SM22预测AMI发生肠坏死的ROC曲线下面积大于I-FABP、SM22单独预测(P均<0.05)。结论血清I-FABP、SM22水平升高的AMI患者易发生肠坏死,二者可作为AMI发生肠坏死的预测指标。Objective To investigate the predictive value of serum intestinal fatty-acid binding protein(I-FABP)and smooth muscle 22(SM22)levels on intestinal necrosis in patients with acute mesenteric ischemia(AMI).Methods Totally 167 patients with AMI were divided into the intestinal necrosis group(58 cases)and non-intestinal necrosis group(109 cases).The clinical data of AMI patients were collected,and the serum I-FABP and SM22 were detected by ELISA.Multivariate Logistic regression was used to analyze the influencing factors for intestinal necrosis in AMI,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum I-FABP and SM22 levels on intestinal necrosis in AMI.Results Multivariate Logistic regression analysis showed that lactic acid,leukocyte count,I-FABP and SM22 were the influencing factors for intestinal necrosis in AMI(all P<0.05).The area under ROC curve of I-FABP+SM22 in predicting intestinal necrosis of AMI patients was greater than that of I-FABP and SM22 alone(both P<0.05).Conclusion AMI patients with elevated serum levels of I-FABP and SM22 are prone to intestinal necrosis,and serum levels of I-FABP and SM22 can be used as predictors of intestinal necrosis in AMI.

关 键 词：急性肠系膜缺血 肠坏死 肠型脂肪酸结合蛋白 平滑肌22 

分 类 号：R572.3[医药卫生—消化系统]