能量代谢与氧化应激在肿瘤中的作用及其相互关系  

Role and relationship between energy metabolism and oxidative stress in tumor

作　　者：阎鑫宇 张绍林 陈海燕[1] 戴琴升[1] YAN Xin-yu;ZHANG Shao-lin;CHEN Hai-yan;DAI Qin-sheng(China Pharmaceutical University,Nanjing 210009)

机构地区：[1]中国药科大学,南京210009

出　　处：《中南药学》2022年第6期1373-1378,共6页Central South Pharmacy

基　　金：国家自然基金青年科学基金项目(No.NSFC82001891);杰出青年基金项目(No.BK20190028)。

摘　　要：肿瘤细胞的发展是一个快速增殖的过程,在此过程中需要大量的能量供应,而这些能量主要通过细胞的糖代谢来提供,少量由谷氨酰胺代谢及脂肪酸代谢补充生成。伴随着线粒体呼吸链三磷酸腺苷(ATP)的生成,肿瘤细胞会产生大量的活性氧(ROS),使其处在一个相比于正常细胞ROS水平更高的环境中。众所周知,过量的ROS会造成细胞损伤甚至死亡,然而肿瘤细胞却能够在高ROS的环境中继续发生发展。本文主要通过对能量代谢及氧化应激的介绍来简单阐述肿瘤细胞中能量代谢与氧化应激之间的相互作用,为后续的肿瘤研究提供理论依据。Tumor cells can rapidly proliferate.In this process,a large amount of energy is required,which is mainly provided by glucose metabolism,and a small amount is supplemented by glutamine metabolism and fatty acid metabolism.With the generation of adenosine triphosphate(ATP)from the mitochondrial respiratory chain,tumor cells will produce a lot of reactive oxygen(ROS),the exposing cell to an environment with higher ROS levels than needed by normal cells.Excessive ROS can cause cell injury or even death,but tumor cells can continue to develop in a high ROS environment.This review mainly explained energy metabolism,oxidative stress and the interactions between them to provide a theoretical basis for future research on tumor.

关 键 词：肿瘤 能量代谢 氧化应激 活性氧 

分 类 号：R730[医药卫生—肿瘤]