原发性肝癌患者血清PTN、GP73、FGF19检测的意义  

Detection Significance of serum PTN,GP73 and FGF19 in patients with primary liver cancer

作　　者：赵景曼 杨颖[1] 张晓春 石荣亚 田芳 ZHAO Jingman;YANG Ying;ZHANG Xiaochun;SHI Rongya;TIAN Fang(Department of Geriatrics,Baoding First Hospital of Traditional Chinese Medicine,Baoding,Hebei 071000,China;Department of Gastroenterology,Baoding People′s Hospital,Baoding,Hebei 071000,China)

机构地区：[1]河北省保定市第一中医院老年病科,河北保定071000 [2]河北省保定市人民医院消化科,河北保定071000

出　　处：《检验医学与临床》2022年第13期1804-1807,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨原发性肝癌患者血清多效生长因子(PTN)、高尔基体跨膜糖蛋白73(GP73)、成纤维细胞生长因子19(FGF19)水平及检测意义。方法选取保定市第一中医院2019年3月至2021年4月确诊的80例原发性肝癌患者作为肝癌组,另选取同期在保定市第一中医院体检的80例健康者作为对照组,以及80例其他良性肝病患者作为良性组,所有研究对象均进行血清PTN、GP73、FGF19水平检测,并进行组间比较。对肝癌组患者以不同临床特征进行分组观察。比较对照组、良性组和肝癌组患者血小板计数、清蛋白、天门冬氨酸氨基转移酶(AST)/丙氨酸氨基转移酶(ALT)差异,并分析血清PTN、GP73、FGF19水平与血小板计数、清蛋白、AST/ALT的相关性。结果肝癌组患者血清GP73、FGF19、PTN水平均明显高于良性组和对照组,良性组患者又明显高于对照组,差异均有统计学意义(P<0.05)。不同性别、年龄肝癌患者血清GP73、FGF19、PTN水平比较,差异均无统计学意义(P>0.05)。TNM分期为Ⅲ+Ⅳ期、肿瘤最大径>5 cm、有淋巴结转移、有肝硬化肝癌患者血清GP73、FGF19、PTN水平均明显高于TNM分期为Ⅰ+Ⅱ期、肿瘤最大径≤5 cm、无淋巴结转移、无肝硬化肝癌患者,差异均有统计学意义(P<0.05)。肝癌组患者血小板计数、清蛋白水平均低于良性组和对照组,良性组患者又低于对照组,差异均有统计学意义(P<0.05)。肝癌组患者AST/ALT高于良性组和对照组,良性组患者又高于对照组,差异均有统计学意义(P<0.05)。血清GP73、FGF19、PTN水平与血小板计数、清蛋白水平均呈负相关(P<0.05),与AST/ALT呈正相关(P<0.05)。结论血清GP73、FGF19、PTN水平与原发性肝癌患者TNM分期、有无淋巴结转移、肿瘤最大径等临床特征有关,血清GP73、FGF19和PTN可用于原发性肝癌的辅助诊断,并且与血小板计数、清蛋白、AST/ALT具有相关性,可作为肝功能损伤评估的辅助指标。Objective To explore the levels and detection significance of serum pleiotropic growth factor(PTN),Golgi transmembrane glycoprotein 73(GP73)and fibroblast growth factor 19(FGF19)in patients with primary liver cancer.Methods A total of 80 patients with primary liver cancer diagnosed in Baoding First Hospital of Traditional Chinese Medicine from March 2019 to April 2021 were selected as the liver cancer group,and 80 healthy people who underwent physical examination in Baoding First Hospital of Traditional Chinese Medicine during the same period were selected as the control group,and 80 patients with other benign liver diseases as the benign group.All subjects were detected serum PTN,GP73 and FGF19 levels,and compared among groups.The patients in the liver cancer group were grouped and observed according to different clinical characteristics.The differences of platelet count,albumin,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)in the control group,benign group and liver cancer group were compared,and the correlation between serum PTN,GP73,FGF19 levels between platelet count,albumin and AST/ALT were analyzed.Results The serum levels of GP73,FGF19 and PTN in the liver cancer group were significantly higher than those in the benign group and the control group,and the benign group were significantly higher than the control group,the differences were statistically significant(P<0.05).There was no significant difference in serum GP73,FGF19 and PTN levels in patients with liver cancer of different genders and ages(P>0.05).The serum GP73,FGF19 and PTN levels of liver cancer patients with TNM stageⅢ+Ⅳ,maximum tumor diameter>5 cm,lymph node metastasis,and with liver cirrhosis were significantly higher than those in liver cancer patients with TNM stageⅠ+Ⅱ,tumor maximum diameter≤5 cm,no lymph node metastasis,no liver cirrhosis,the differences were statistically significant(P<0.05).The platelet count and albumin level in the liver cancer group were lower than those in the benign group and the control gr

关 键 词：原发性肝癌 多效生长因子 高尔基体跨膜糖蛋白73 成纤维细胞生长因子19 

分 类 号：R735.7[医药卫生—肿瘤] R446.1[医药卫生—临床医学]