2%盐酸米诺环素软膏对慢性牙周炎患者IL-17、TNF-α、sICAM-1的影响  

Effects of 2% minocycline hydrochloride ointment on IL-17,TNF-α and sICAM-1 in patients with chronic periodontitis

作　　者：蔡晨雨 蔡世新 李媛媛 张建芬[2] CAI Chenyu;CAI Shixin;LI Yuanyuan;ZHANG Jianfen(Department of Orthodontics and Prosthodontics,Hengshui People's Hospital,Hengshui,Hebei,China,053000;Department of Oral Medicine,Shijiazhuang Medical College,Shijiazhuang,Hebei,China,050000)

机构地区：[1]衡水市人民医院口腔正畸修复科,河北衡水053000 [2]石家庄医学高等专科学校口内教研,河北石家庄050000

出　　处：《分子诊断与治疗杂志》2022年第6期1016-1019,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河北省医学科学研究重点课题计划(20161713)。

摘　　要：目的 探究2%盐酸米诺环素软膏联合甲硝唑棒治疗慢性牙周炎的疗效及对患者龈沟液及血清中白介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、可溶性细胞间黏附分子-1(sICAM-1)水平的影响。方法 选取本院口腔内科2015年9月至2018年2月期间收治的90例慢性牙周炎患者为研究对象,以随机数字表法分为A、B两组,各45例。前者给予甲硝唑棒治疗,后者给予2%盐酸米诺环素软膏联合甲硝唑棒治疗,均治疗4周。观察和评估治疗后牙周改善情况,治疗前后获取龈沟液样本、血清标本,测定炎症因子IL-17、TNF-α、sICAM-1水平,并进行近期疗效判定。结果 两组治疗后牙菌斑指数(PLI)、牙周附着水平(PAL)、牙周袋深度(PPD)及牙龈出血指数(GI)均较治疗前明显降低,且B组下降更明显,差异均有统计学意义(P<0.05)。两组治疗后龈沟液及血清中IL-17、TNF-α、sICAM-1水平均较治疗前明显降低,且B组下降更明显,差异均有统计学意义(P<0.05)。A组、B组治疗后总有效率分别为75.56%、91.11%,差异有统计学意义(P<0.05)。结论 2%盐酸米诺环素软膏联合甲硝唑棒治疗可有效改善慢性牙周炎患者牙周状况,抑制牙周组织炎性反应,提高临床治疗疗效。Objective To investigate the effect of 2% minocycline hydrochloride ointment combined with metronidazole stick in the treatment of chronic periodontitis and its effect on levels of interleukin-17(IL-17),tumor necrosis factor-α(TNF-α)and soluble intercellular adhesion molecule-1(sICAM-1)in gingival crevicular fluid and serum of patients with chronic periodontitis. Methods A total of 90 patients with chronic periodontitis who were admitted to the Department of Oral Medicine of our hospital from September2015 to February 2018 were selected as the research objects. They were randomly divided into group A and group B,45 cases in each group. The former was treated with metronidazole stilus,and the latter was treated with 2% minocycline hydrochloride ointment combined with metronidazole stilus. Both groups were given 4weeks of treatment. The periodontal improvement after treatment was observed and evaluated. Gingival crevicular fluid samples and serum samples were collected before and after treatment to determine the levels of inflammatory factors(IL-17,TNF-α,sICAM-1)and evaluate the short-term curative effect. Results After treatment,the plaque index(PLI),periodontal attachment level(PAL),periodontal pocket depth(PPD)and gingival bleeding index(GI) in the two groups were significantly decreased compared with those beforetreatment,and the decrease in group B was more obvious. There was statistical significance(P<0.05). After treatment,the levels of IL-17,TNF-α,and s ICAM-1 in gingival crevicular fluid and serum in the two groups were significantly decreased compared with those before treatment,and the decrease in group B was more obvious,and the differences were statistically significant(P<0.05). The total effective rates of group A and group B after treatment were 75.56% and 91.11%,respectively,and the difference was statistically significant(P<0.05).(P<0.05). Conclusion 2% minocycline hydrochloride ointment combined with metronidazole stilus can effectively improve the periodontal status of patients with chronic p

关 键 词：盐酸米诺环素软膏 甲硝唑棒 慢性牙周炎 炎性反应 

分 类 号：R781.42[医药卫生—口腔医学]