TAMs、PRL-3和C-erbB-2与乳腺癌淋巴结转移及预后的相关性  

Correlation of TAMs,PRL-3 and C-erbB-2 with lymph node metastasis and prognosis of breast cancer

作　　者：王丽娟 林晓茹 陈云婷 陈露文 WANG Lijuan;LIN Xiaoru;CHEN Yunting;CHEN Luwen(Department of Surgery Breast Disease,Maternal and Child Care Service Center of Sanya,Sanya,Hainan,China,572000;Department of Breast Cancer,Jiangxi Ganzhou Cancer Hospital,Ganzhou,Jiangxi,China,341000)

机构地区：[1]上海儿童医学中心三亚市妇女儿童医院(三亚市妇幼保健院)乳腺科,海南三亚572000 [2]江西赣州肿瘤医院乳腺科,江西赣州341000

出　　处：《分子诊断与治疗杂志》2022年第6期1044-1047,1051,共5页Journal of Molecular Diagnostics and Therapy

摘　　要：目的 分析肿瘤相关巨噬细胞(TAMs)、肝再生磷酸酶(PRL-3)及人类表皮生长因子受体2(C-erbB-2)与乳腺癌淋巴结转移及预后的相关性。方法 收集2017年5月至2020年5月海南省三亚市妇女儿童医院收治的115例乳腺癌患者,以其术后病理组织作为观察组,并取患者距肿瘤切缘>5cm远癌组织作为对照组;淋巴结转移者(转移组)46例,未转移者(无转移组)69例。比较不同组织、有无淋巴结转移者血TAMs、PRL-3及C-erbB-2表达情况,分析影响乳腺癌预后不良的相关因素。结果观察组TAMs、PRL-3及C-erbB-2阳性表达均明显高于对照组,差异有统计学意义(P<0.05)。转移组TAMs、PRL-3及C-erbB-2阳性表达率明显高于无转移组,差异有统计学意义(P<0.05)。115例患者随访12个月后生存88例,预后不良27例。预后不良组淋巴结转移者、病理分期为Ⅲ~Ⅳ期、低分化、TAMs阳性、PRL-3阳性、C-erbB-2阳性占比明显高于预后良好组,差异有统计学意义(P<0.05)。Logistic回归模型分析显示,病理分期、分化程度、淋巴结转移情况、TAMs、PRL-3及C-erbB-2为影响乳腺癌患者预后不良的独立危险因素(P<0.05)。结论 TAMs、PRL-3及C-erbB-2过度表达与乳腺癌淋巴结转移可能存在一定的联系,对乳腺癌患者预后评估有参考价值。Objective To analyze the correlation between tumor-associated macrophages(TAMs),regenerative phosphatase-3(PRL-3),human epidermal growth factor receptor 2(C-erbB-2)and lymph node metastasis and prognosis of breast cancer. Methods A total of 115 breast cancer patients admitted to Sanya Women and Children’s Hospital,Hainan Province from May 2017 to May 2020 were collected,with postoperative pathological tissue as the observation group. The patients with no cancerous tissues>0.5 cm from the tumor resection margin were taken as the control group;46 cases of lymph node metastasis(metastasis group),69 cases of underemployed(non-metastasis group). The expression of TAMs,PRL-3 and C-erbB-2in the blood of patients with different tissues and with or without lymph node metastasis were compared,and the related factors affecting the poor prognosis of breast cancer were analyzed. Results The positive expression of TAMs,PRL-3 and C-erbB-2 in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05). The positive expression rate of TAMs,PRL-3 and C-erbB-2 in the metastatic group was significantly higher than that in the non-metastasis group,andthe difference was statistically significant(P<0.05). Of the 115 patients,88 survived after 12 months of followup,and 27 had poor prognosis. The proportion of lymph node metastasis,pathological stage Ⅲ-Ⅳ,poorly differentiated,positive for TAMs,positive for PRL-3 and positive for C-erb B-2 in the poor prognosis group was significantly higher than that in the good prognosis group,and the difference was statistically significant(P<0.05). There was no statistically significant difference in genders and ages(P>0.05). Logistic regression model analysis showed that pathological stage,degree of differentiation,lymph node metastasis,TAMs,PRL-3 and C-erb B-2 were independent risk factors affecting the poor prognosis of breast cancer patients(P<0.05).Conclusion The overexpression of TAMs,PRL-3 and C-erb B-2 may be re

关 键 词：TAMS PRL-3 C-ERBB-2 乳腺癌 淋巴结转移 

分 类 号：R737.9[医药卫生—肿瘤]