血清MMP-9、COX-2、CGRP对偏头痛经导管封堵PFO预后的预测价值  

Predictive value of serum MMP-9,COX-2,and CGRP on prognosis of transcatheter occlusion of PFO in migraine

作　　者：马杰[1] 廖红娟[1] 张焱 李璐瑜 张洁琼 赵曙光[1] MA Jie;LIAO Hongjuan;ZHANG Yan;LI Luyu;ZHANG Jieqiong;ZHAO Shuguang(Department of Cardiac Surgery,the Second Hospital of Hebei Medical University,Shijiazhuang,Hebei,China,050000)

机构地区：[1]河北医科大学第二医院心脏外科,河北石家庄050000

出　　处：《分子诊断与治疗杂志》2022年第6期1052-1055,1059,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河北省医学科学研究课题计划立项(20221048)。

摘　　要：目的 探究血清基质金属蛋白酶-9(MMP-9)、环氧合酶-2(COX-2)、降钙素基因相关肽(CGRP)对偏头痛经导管封堵卵圆孔未闭(PFO)预后的预测价值。方法 选取233例经导管封堵PFO偏头痛患者作为观察组,另选取健康体检者60名作为对照组。检测其MMP-9、COX-2、CGR水平。结果 观察组血清MMP-9、COX-2、CGRP水平均较对照组高,差异有统计学意义(P<0.05)。预后不良患者MMP-9、COX-2、CGRP入院时与术后7 d差值绝对值较预后良好患者小(P<0.05)。偏头痛患者MMP-9、COX-2、CGRP入院时与术后7 d差值绝对值间呈正相关关系(P<0.05)。三者联合预测偏头痛经导管封堵PFO预后的AUC为0.926(95%CI:0.884~0.956),较各指标单独预测价值明显提高(P<0.05)。结论 偏头痛经导管封堵PFO术后血清MMP-9、COX-2、CGRP水平明显下降,且其下降幅度与临床预后有关,动态检测其水平,有助于该病患者预后预测。Objective To investigate the predictive value of serum matrix metalloproteinase-9(MMP-9),cyclooxygenase-2(COX-2),and calcitonin gene-related peptide(CGRP)on the prognosis of transcatheter occlusion of patent foramen ovale(PFO)in migraine. Methods Two hundred and thirty-three patients with transcatheter occlusion of PFO migraine were selected as the observation group,and another 60healthy physical examiners were selected as the control group. Their MMP-9,COX-2 and CGR levels were detected. Results The serum MMP-9,COX-2,and CGRP levels were higher in the observation group than those in the control group(P<0.05). The absolute values of the difference between MMP-9,COX-2,and CGRP at admission and 7 d after surgery were smaller in patients with poor prognosis than those in patients with good prognosis(P<0.05). There was a positive correlation between the absolute values of MMP-9,COX-2,and CGRP differences at admission and 7 d postoperatively in migraine patients(P<0.05). The AUC for the combination of the three to predict the prognosis of transcatheter occlusion of PFO in migraine was 0.926(95% CI:0.884 to 0.956),which was significantly higher than the predictive value of each indicator alone(P<0.05). Conclusion Serum levels of MMP-9,COX-2,and CGRP decreased significantly after transcatheter occlusion of PFO in migraine,and the magnitude of their decrease was related to clinical prognosis.Dynamic detection of their levels could help predict the prognosis of patients with this disease.

关 键 词：卵圆孔未闭 经导管封堵术 MMP-9 COX-2 CGRP 偏头痛 

分 类 号：R747.2[医药卫生—神经病学与精神病学]