基于肠道菌群探讨水合橙皮内酯对AS抑郁症共病模型大鼠的调节作用  

Meranzin Hydrate Effects Atherosclerosis and Depressive Comorbidity in ApoE Rats by Antidyslipidemic,Anti-Inflammatory and Regulate Intestinal Flora

作　　者：王喆 孙波 任平 黄熙[1] WANG Zhe;SUN Bo;REN Ping;HUANG Xi(School of Chinese Medicine,School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学中医学院·中西医结合学院,江苏南京210023 [2]南京中医药大学附属医院,江苏南京210029

出　　处：《南京中医药大学学报》2022年第6期511-519,共9页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏高校优势学科建设工程项目(中西医结合)(035062005002-21);南京中医药大学高层次人才项目;国家自然科学基金面上项目(81973589,81173591)。

摘　　要：目的分析水合橙皮内酯(Meranzin hydrate,MH)治疗AS和抑郁共病的疗效,探讨药物的作用机理。方法实验采用维持饲料饲养SD大鼠作为对照组,高脂饲料饲养ApoE^(-/-)大鼠12周建立AS抑郁症共病模型,并随机分为模型组和干预组(MH3.5 mg·kg^(-1)、MH 7 mg·kg^(-1)和辛伐他汀7 mg·kg^(-1)),每组6只。结果MH干预能有效降低血浆和海马促炎因子TNF-α、IL-1β和IL-6水平,调整血脂水平,下调主动脉斑块面积,增加海马5-羟色胺(5-Hydroxytryptamine,5-HT)水平,改善大鼠抑郁样行为,调整肠道菌群结构。结论MH通过抗炎调脂,调整肠道菌群结构从而发挥抗AS抑郁共病的作用。OBJECTIVE Focus on the efficacy of Meranzin hydrate(MH)in the treatment of comorbid AS and depression,and dicuss the mechanism of MH.METHODS Sprague Dawley rats with chow diets were elected as the control group,and ApoE^(-/-) rats were fed high-fat diets for 12 weeks to establish the AS multimorbidity with depression model.ApoE^(-/-) rats were randomly divided into the model group and intervention groups(MH 3.5 mg·kg^(-1),MH 7 mg·kg^(-1),and simvastatin 7 mg·kg^(-1) groups).n=6,for each group.RESULTS Treatment of comorbid AS and depression with MH could significantly decrease lipid levels,plaque areas,plasma level of inflammatory factors and hippocampus inflammatory cytokines,particularly tumor necrosis factor-α,interleukin(IL)-1β,and IL-6.MH could also improve hippocampal 5-hydroxytryptamine levels as well as depressive-like behavior and regulate intestinal flora.CONCLUSION This study demonstrates that MH reduces the inflammatory response as well as lipid levels and improves the composition of intestinal flora,which plays an important role against AS multimorbidity with depression.

关 键 词：动脉粥样硬化 高脂饮食 肠道菌群 炎症 抑郁症 水合橙皮内酯 

分 类 号：R285.5[医药卫生—中药学]