阿魏酸和白芷提取物对1例额叶变异型阿尔茨海默病患者的临床疗效  

Feru-guard Improves Cognitive Dysfunction in the Frontal Variant of Alzheimer's Disease:A Case Report

作　　者：邱国真 许春燕 郭启雯 朱飞奇[1] QIU Guo zhen;XU Chun yan;GUO Qi wen;ZHU Fei qi(Cognitive Impairment Ward of Neurology Department,The Third Affiliated Hospital ofShenzhen University,Shenzhen,Shenzhen,Guangdong Province 518001,China)

机构地区：[1]深圳大学第三附属医院神经内科认知障碍病区,广东深圳518001

出　　处：《阿尔茨海默病及相关病杂志》2022年第2期139-142,共4页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：深圳市科技创新委员会基础研究项目(JCYJ20180302153449519);深圳市三名工程项目(SZSM201801014)资助。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)也被称为老年性痴呆,是一种伴有精神行为改变和日常生活能力减退的神经退行性疾病,β-淀粉样蛋白(amyloidβ-protein,Aβ)沉积形成的老年斑及过度磷酸化Tau蛋白形成的神经原纤维缠结(neurofibrillary tangles,NFTs)是其组织病理学特征。AD分为典型AD和非典型AD。后皮层变异性AD、Logopenic失语AD和额叶变异型AD(frontal variant of AD,Fv AD)均为非典型AD,其中FvAD临床明显特征是患者在痴呆的早期即出现额叶功能的严重受损。阿魏酸和白芷提取物(Feru-guard)是一种膳食补充剂,近年来在治疗痴呆伴发精神行为障碍(behavioral and psychological symptoms of dementia,BPSD)方面的疗效引起了相关学者的广泛关注。本文报道了Feru-guard治疗1例FvAD患者的临床疗效,并详细回顾了其诊治过程。Alzheimer’s disease(AD, also known as senile dementia) is a neurodegenerative disease characterized by progressive cognitive decline associated with behavioral and psychological symptoms and the reduction of daily activities. The pathological characteristics of AD include the deposition of amyloid beta(Aβ), neurofibrillary tangles(NFTs). The International Working Group(IWG) has divided AD into two different types, the typical form and the atypical form, the latter including the posterior variant, the logopenic variant and the frontal variant AD(Fv AD). The most obvious clinical feature of patients with Fv AD is the severe impairment on frontal lobe function. Feru-guard, a dietary supplement containing ferulic acid and Angelica archangelica, has attracted much interest recently due to the discovery of beneficial effects in the treatment of behavioral and psychological symptoms of dementia(BPSD). Here we present a case of improvement of cognitive dysfunction in a patient with Fv AD after Feru-guard therapy.

关 键 词：阿尔茨海默病 阿魏酸和白芷提取物 额叶变异型 精神行为异常 认知功能障碍 

分 类 号：R741.02[医药卫生—神经病学与精神病学]